Effective voltammetric tool for simultaneous detection of MMP-1, MMP-2, and MMP-9; important non-small cell lung cancer biomarkers

Kowalczyk, Agata; Nisiewicz, Monika K.; Bamburowicz-Klimkowska, Magdalena; Kasprzak, Artur; Ruzycka-Ayoush, Monika; Koszytkowska‐Stawińska, Mariola; Nowicka, Anna M.

doi:10.1016/j.bios.2023.115212

Cited by 12 publications

(4 citation statements)

References 72 publications

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“…[25][26][27] MMP-2 and MMP-9 are considered as potential biomarkers in the process of tumorigenesis, as well as key effectors of ECM remodeling and important potential targets for anti-tumor therapy. 28,29 The ECM degradation caused by MMPs will lead to an increased C-IV level in serum. 30 Therefore, logically, C-IV level in serum may be positively correlated with the risk of tumor.…”

Section: Discussionmentioning

confidence: 99%

Novel Preoperative Type IV Collagen to Predict the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhotic Portal Hypertension After Laparoscopic Splenectomy and Azygoportal Disconnection

Gao,

Jin,

Fang

et al. 2024

JHC

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Purpose Although laparoscopic splenectomy and azygoportal disconnection (LSD) can significantly decrease portal vein pressure and even the incidence of hepatocellular carcinoma (HCC) in patients with cirrhotic portal hypertension (CPH), postoperative HCC inevitably occurs in certain patients. The purpose of this study was to seek a novel preoperative non-invasive predictive indicator to predict the occurrence of postoperative HCC. Patients and Methods From April 2012 to April 2022, we collected clinical data of 178 hepatitis B virus (HBV)-related CPH patients. Based on inverse treatment probability weighting, candidate variables for predicting postoperative HCC were determined by means analysis. Then, a novel preoperative non-invasive prediction indicator (ie, type IV collagen-alpha fetoprotein-fibrosis-4 score [IVAF-FIB-4]) was established based on candidate variables, and its predictive ability was explored. Results Postoperative HCC occurred in 9 (5.1%) patients. Correlation analyses showed that the IVAF-FIB-4 had a significant positive correlation with HCC (r = 0.835, P < 0.001). IVAF-FIB-4 showed a high accuracy (the area under the receiver operating characteristic curve: 0.939, 95% confidence interval [CI]: 0.818–1.000; sensitivity: 88.9%; specificity: 93.5%). At the end of follow-up, the incidence density of HCC in patients with IVAF-FIB-4 (1) was significant higher than that in patients with IVAF-FIB-4 (0) (138.1/1000 vs 1.1/1000 person-years; rate ratio: 130.475, 95% CI: 16.318–1043.227). In logistic regression, IVAF-FIB-4 was an independent risk factor for HCC (odds ratio: 668.000, 95% CI: 53.895–8279.541; P < 0.001). Conclusion IVAF-FIB-4 is a novel preoperative noninvasive predictive indicator for predicting postoperative HCC in HBV-related CPH patients after LSD, with satisfactory predictive ability.

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Section: Discussionmentioning

confidence: 99%

Novel Preoperative Type IV Collagen to Predict the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhotic Portal Hypertension After Laparoscopic Splenectomy and Azygoportal Disconnection

Gao,

Jin,

Fang

et al. 2024

JHC

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“…Emerging evidence suggests that there is a decrease in the overall balance between excitatory and inhibitory activity in the cortex of individuals with MDD. The presence of MMP9 in plasma, lung tissue, and tumor extracts can facilitate the early detection and diagnosis of lung cancer 64 and it has been shown to augment the migratory, invasive, and EMT properties of NSCLC cells 65 . As a result of neuronal activity, MMP9 has been found to contribute to the antidepressant effectiveness of venlafaxine, a serotonin/norepinephrine reuptake inhibitor, in male mice 66 .…”

Section: Discussionmentioning

confidence: 99%

“…facilitate the early detection and diagnosis of lung cancer 64 and it has been shown to augment the migratory, invasive, and EMT properties of NSCLC cells. 65 As a result of neuronal activity, MMP9 has been found to contribute to the antidepressant effectiveness of venlafaxine, a serotonin/norepinephrine reuptake inhibitor, in male mice.…”

Section: The Shared Genes and Pathway Targets Are Present Between Mdd...mentioning

confidence: 99%

Enhancing the revelation of key genes and interaction networks in non‐small cell lung cancer with major depressive disorder: A bioinformatics analysis

Gui,

Chen,

Nie

et al. 2024

Health Science Reports

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Background and AimsLung cancer is ranked as the second most prevalent form of cancer worldwide. Nonsmall cell lung cancer (NSCLC) represents the predominant histological subtype. Research suggests that one‐third of lung cancer patients also experiencing depression. Antidepressants play an indispensable role in the management of NSCLC. Despite significant advancements in treatment, lung cancer patients still face a high mortality rate. Major depressive disorder (MDD) and related antidepressants involved in treatment efficacy and prognosis of NSCLC. However, there has been a lack of screening and analysis regarding genes and networks associated with both NSCLC and MDD.MethodsTo investigate the correlation between MDD and NSCLC, our discovery and validation analysis included four datasets from the Gene Expression Omnibus database from NSCLC or MDD. Differential gene expression (DEGs) analysis, GO and KEGG Pathway, and protein‐protein interaction network analyzes to identify hub genes, networks, and associated observations link between MDD and NSCLC.ResultsThe analysis of two datasets yielded a total of 84 downregulated and 52 upregulated DEGs. Pathway enrichment analyzes indicated that co‐upregulated genes were enriched in the regulation of positive regulation of cellular development, collagen‐containing extracellular matrix (ECM), cytokine binding, and axon guidance. We identified 20 key genes, which were further analyzed using the MCODE plugin to identify two core subnetworks. The integration of functionally similar genes provided valuable insights into the potential involvement of these hub genes in diverse biological processes including angiogenesis humoral immune response regulation inflammatory response organization ECM network.ConclusionWe have identified a total of 136 DEGs that participate in multiple biological signaling pathways. A total of 20 hub genes have demonstrated robust associations, potentially indicating novel diagnostic and therapeutic targets for both diseases.

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“…Unfortunately, the practical application of these methods in clinical diagnosis is limited by several shortcomings such as tedious operation, the need for expensive and complex instruments, low sensitivity, or the demand for large volumes of samples. To overcome these problems, several sensing methods including fluorescence, 9 electrochemistry, 10 surface plasmon resonance (SPR), 11 colorimetry, 12 surface-enhanced Raman scattering (SERS), 13 etc. have been established for sensitive detection of exosomes.…”

mentioning

confidence: 99%

Methylene Blue-Stained Single-Stranded DNA Aptamers as a Highly Efficient Electronic Switch for Quasi-Reagentless Exosomes Detection: An Old Dog with New Tricks

Wang,

Jie,

et al. 2023

Anal. Chem.

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Effective voltammetric tool for simultaneous detection of MMP-1, MMP-2, and MMP-9; important non-small cell lung cancer biomarkers

Cited by 12 publications

References 72 publications

Novel Preoperative Type IV Collagen to Predict the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhotic Portal Hypertension After Laparoscopic Splenectomy and Azygoportal Disconnection

Novel Preoperative Type IV Collagen to Predict the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhotic Portal Hypertension After Laparoscopic Splenectomy and Azygoportal Disconnection

Enhancing the revelation of key genes and interaction networks in non‐small cell lung cancer with major depressive disorder: A bioinformatics analysis

Methylene Blue-Stained Single-Stranded DNA Aptamers as a Highly Efficient Electronic Switch for Quasi-Reagentless Exosomes Detection: An Old Dog with New Tricks

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