Effective Use of Keishibukuryogan in Subcutaneous Hematoma after Implantable Cardiac Device Surgery in Two Cases

Kumanomido, Jun; Ohe, Masatsugu; Shibata, Ryoko; Hattori, Yuichi; Ishizaki, Yuta; Ito, Shogo; Nohara, Yume; Takahashi, J; Hori, Katsuo; Obuchi, Aya; Ohtsuka, Masanori

doi:10.2169/internalmedicine.5677-20

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…They were attached to adipose (Ad) tissues on their outer, while their inner surfaces (adjacent to implant) were smooth, slippery, and lined with interstitial fluid [18, 42]. Localized blood patches (subcutaneous hematoma) were observed on inner sides in 3/5 (60%) and 1/2 (50%) of Fb-P (samples 1, 3, and 5) and Fb-PECM (1), likely due to the surgical procedure [43]. No signs of swelling were noticed.…”

Section: Resultsmentioning

confidence: 99%

Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model

Guzman

Meer

Mathews

et al. 2022

Preprint

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BACKGROUND: Fibrous capsules (Fb) in response to cardiovascular implantable electronic devices (CIEDs) including a pacemaker (P) system, can produce patient discomfort and difficulties in revision surgery due to their high compressive strength, potentially via elevated elastic fibers. OBJECTIVE: To determine if biologic extracellular matrix-enveloped CIEDs (PECM) caused differential Fb properties. METHODS: Retrieved Fb (-P and -PECM) from minipigs were subjected to biomechanical (shear oscillation and uniaxial compression) and histological (collagen I and elastin) analyzes. RESULTS: Fb-PECM showed significant decreases compared to Fb-P at: low strain-loss modulus (390 vs. 541 Pa) across angular frequencies, high strain-compressive elastic modulus (1043 vs. 2042 kPa), and elastic fiber content (1.92 vs. 3.15 μg/mg tissue), particularly closer to the implant's surface (71% vs. 143% relative to skin dermis elastin) and verified with a solid mechanics hyperelasticity with direction-dependent fiber viscoelasticity compression simulation (r2 ≥ 98.9%). CONCLUSIONS: The biocompatible wrap composed of decellularized porcine ECM for CIEDs generated fibrous tissues with less elastic fibers which contributed to a more desirable material mechanics.

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Section: Resultsmentioning

confidence: 99%

Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model

Guzman

Meer

Mathews

et al. 2022

Preprint

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“…In university hospital, KBG was used for treating hematoma in emergency department (60). Kumanomido et al reported that KBG diminished subcutaneous hematoma after surgery in a case report (61). RCT also suggests that in elderly subjects, KBG improved deep vein thrombosis of lower limb (62).…”

Section: Varicose Vein Hematoma and Deep Vein Thrombosismentioning

confidence: 99%

A Review on the Mechanism and Application of Keishibukuryogan

2021

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The concept of “blood stasis” – called yū xiě in Chinese, Oketsu in Japanese – is one of the unique pathophysiology of traditional medicine that originated in China and inherited in Korea and Japan. This concept is related to the multiple aspects of hemodynamic disorders brought on by quantitative and qualitative changes. It theorizes that the quantitative changes of “blood stasis” are related to peripheral circulatory insufficiency. When chronic qualitative changes of “blood stasis” produce stagnant blood that turns into a pathological product, it could cause inflammation and lead to organic changes. Trauma induced hematomas, that are considered to be a quantitative change of blood, are also a form of blood stasis. The basic medicine research on Keishibukuryogan (KBG)–a Japanese name in Traditional Japanese Medicine (Kampo) for one of the most common anti- “blood stasis” prescriptions, also known as gui-zhi-fu-ling-wan (GFW) in Chinese in Traditional Chinese Medicine (TCM)–indicated that the initiation of quantitative changes was closely related to loss of redox balances on endothelial function induced by oxidative stress. The following qualitative changes were related to coagulopathy, hyper viscosity; anti-platelet aggregation, lipid metabolism; a regulation of systemic leptin level and/or lipid metabolism, inflammatory factor; cyclooxygenase-1,2 (COX-1, 2), interleukin-6, 8 tumor necrosis factor-α, macrophage infiltration, hyperplasia, tissue fibrosis and sclerosis caused by transforming growth factor-β1 and fibronectin, the dysfunction of regulated cell deaths, such as, apoptosis, autophagy, ferroptosis and ovarian hormone imbalance. Clinically, KBG was often used for diseases related to Obstetrics and Gynecology, Endocrine Metabolism, Rheumatology and Dermatology. In this review, we give an overview of the mechanism and its current clinical application of KBG through a summary of the basic and clinical research and discuss future perspective.

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Effective Use of Keishibukuryogan in Subcutaneous Hematoma after Implantable Cardiac Device Surgery in Two Cases

Cited by 2 publications

References 8 publications

Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model

Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model

A Review on the Mechanism and Application of Keishibukuryogan

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