Effective use of a two-dose regimen of dalbavancin to treat prosthetic joint infections and spinal hardware infections

Doub, James B.; Alkayali, Talal; Amoroso, Anthony; Nandi, Sumon; Talwani, Rohit

doi:10.1007/s00590-023-03609-8

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…A combination therapy with rifabutin or rifampicin was also administered in 53% of the patients (mainly staphylococcal infections). No adverse effects were observed [50].…”

Section: Bone and Joint Infection (Including Prosthetic Joint Infecti...mentioning

confidence: 85%

The role of long-acting antibiotics in the clinical practice: a narrative review

2023

Infez Med

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L ong-acting antibiotics, such as dalbavancin and oritavancin, have emerged as important tools in the fight against bacterial infections. Ini-tially approved for treating acute bacterial skin and skin structure infections (ABSSSI), they have gained attention for potential off-label use due to their extended half-lives, their excellent tissue penetration, which allows prolonged high therapeutic concentrations at the site of infection in many difficult to treat sites as bone, their in vitro demonstrated efficacy against biofilm, their potent activity against a broad spectrum of Gram-positive bacteria, along with a favourable safety pro-

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“…A combination therapy with rifabutin or rifampicin was also administered in 53% of the patients (mainly staphylococcal infections). No adverse effects were observed [50].…”

Section: Bone and Joint Infection (Including Prosthetic Joint Infecti...mentioning

confidence: 85%

The role of long-acting antibiotics in the clinical practice: a narrative review

2023

Infez Med

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Antibiotics with antibiofilm activity – rifampicin and beyond

Ferreira,

Pos,

Nogueira

et al. 2024

Front. Microbiol.

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The management of prosthetic joint infections is a complex and multilayered process that is additionally complicated by the formation of bacterial biofilm. Foreign material provides the ideal grounds for the development of an intricate matrix that hinders treatment and creates a difficult environment for antibiotics to act. Surgical intervention is often warranted but requires appropriate adjunctive therapy. Despite available guidelines, several aspects of antibiotic therapy with antibiofilm activity lack clear definition. Given the escalating challenges posed by antimicrobial resistance, extended treatment durations, and tolerance issues, it is essential to ensure that antimicrobials with antibiofilm activity are both potent and diverse. Evidence of biofilm-active drugs is highlighted, and alternatives to classical regimens are further discussed.

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New Frontier on Antimicrobial Therapy: Long-Acting Lipoglycopeptides

Siciliano,

Sangiorgi,

Del Vecchio

et al. 2024

Pathogens

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Long-acting lipoglycopeptides (LGPs), such as dalbavancin and oritavancin, are semisynthetic antibiotics known for their strong effectiveness against a wide array of Gram-positive bacteria. This includes Staphylococcus aureus, both methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) strains, coagulase-negative Staphylococci (CoNS), streptococci, and vancomycin-sensitive Enterococcus faecalis. A literature search was conducted on PubMed and on ClinicalTrials.gov to identify articles published until July 2023 investigating the use of oritavancin and dalbavancin in clinical practice. The review included case reports, case series, observational studies, and clinical studies. Although more consistent data are needed, LGPs seem to be a good alternative that may provide a quicker hospital discharge and reduce long-term intravenous access and therapy. This is attributed to their unique pharmacologic and pharmacokinetic characteristics. More quality data (i.e., number of patients treated with clinical success) are needed before clinicians may use these therapies more widely.

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Effective use of a two-dose regimen of dalbavancin to treat prosthetic joint infections and spinal hardware infections

Cited by 3 publications

References 12 publications

The role of long-acting antibiotics in the clinical practice: a narrative review

The role of long-acting antibiotics in the clinical practice: a narrative review

Antibiotics with antibiofilm activity – rifampicin and beyond

New Frontier on Antimicrobial Therapy: Long-Acting Lipoglycopeptides

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