Effective Uptake of Folate-Functionalized Ethionamide-Loaded Hybrid System: Targeting Alveolar Macrophages

Maurya, Priyanka; Saklani, Ravi; Singh, Samipta; Nisha, Raquibun; Mishra, Nidhi; Singh, Priya; Pal, Ravi Raj; Kumar, Abhiram; Chourasia, Manish K.; Saraf, Shubhini A.

doi:10.2217/nnm-2021-0468

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Taken together, the findings of the study can be explored further for QbD optimization and the development of novel OTFs with various drugs in the future. 27,28…”

Section: Discussionmentioning

confidence: 99%

Quality by Design (QbD) Aided Formulation Optimization of Amlodipine Besylate Oral Thin Film

Kumar,

Singh

et al. 2024

Ind. J. Pharm. Edu. Res

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Background: Oral Thin Film (OTF) is an emerging approach for oral drug delivery but still there exists a scarcity of evidence for formulation optimization techniques. Herein, we aim to develop OTFs optimized by the QbD approach. Materials and Methods: OTFs were prepared by solvent casting method using Amlodipine as an active ingredient and excipients such as Pectin, Aspartame, Tween 80, and Glycerine. The developed formulation was optimized using QbD software Design Expert version 8.0.4, USA. The independent variables of the experiment were selected as A-pectin, B-Tween-80, and C-glycerine, and the dependent variables were R1-tensile strength (kg/cm 2 ), R2-permeation rate (µg/cm 2 /hr), R3-disintegration time (in a sec). Finally, the software suggested optimized formulation based on a desirability value closer to 1. Results: The optimized oral films were comparatively evaluated and characterized by various techniques. The drug release was found to be ~96% at 10 min for OTFs and ~94% at 20 min for oral fast-dissolving tablets. The amlodipine was scanned in the UV range of 200 to 400 nm and the λ max was observed to be at 240±2 in a Phosphate of pH 6.8. Conclusion: All results are found satisfactory and well within the acceptance range. This ensures that similar formulations can be optimized by using this technique in the future.

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“…Taken together, the findings of the study can be explored further for QbD optimization and the development of novel OTFs with various drugs in the future. 27,28…”

Section: Discussionmentioning

confidence: 99%

Quality by Design (QbD) Aided Formulation Optimization of Amlodipine Besylate Oral Thin Film

Kumar,

Singh

et al. 2024

Ind. J. Pharm. Edu. Res

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Appraisal of folate functionalized bosutinib cubosomes against hepatic cancer cells: In-vitro, In-silico, and in-vivo pharmacokinetic study

Nisha,

Kumar,

Mishra

et al. 2024

International Journal of Pharmaceutics

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Lipid Nanocarrier Targeting Activated Macrophages for Antiretroviral Therapy of HIV Reservoir

Wu,

Si,

Xue

et al. 2023

Nanomedicine (Lond.)

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Aim: To develop lipid nano-antiretrovirals (LNAs) for the treatment of HIV-infected macrophages. Materials & methods: LNAs were prepared with docosahexaenoic acid to facilitate brain penetration and surface-decorated with folate considering that infected macrophages often overexpress folate receptors. Results: Folate-decorated LNAs loading rilpivirine (RPV) were efficiently taken up by folate receptor-expressing cell types including activated macrophages. The intracellular Cmax of the RPV-LNAs in activated macrophages was 2.54-fold and the area under the curve was 3.4-fold versus free RPV, translating to comparable or higher (p < 0.01; RPV ≤6.5 ng/ml) activities against HIV infectivity and superior protection (p < 0.05) against HIV cytotoxicity. LNAs were also effective in monocyte-derived macrophages. Conclusion: These findings demonstrate the potential of LNAs for the treatment of infected macrophages, which are key players in HIV reservoirs.

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Effective Uptake of Folate-Functionalized Ethionamide-Loaded Hybrid System: Targeting Alveolar Macrophages

Cited by 3 publications

References 26 publications

Quality by Design (QbD) Aided Formulation Optimization of Amlodipine Besylate Oral Thin Film

Quality by Design (QbD) Aided Formulation Optimization of Amlodipine Besylate Oral Thin Film

Appraisal of folate functionalized bosutinib cubosomes against hepatic cancer cells: In-vitro, In-silico, and in-vivo pharmacokinetic study

Lipid Nanocarrier Targeting Activated Macrophages for Antiretroviral Therapy of HIV Reservoir

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