Effective treatment of refractory tinnitus by bilateral deep brain stimulation of the medial geniculate body of the thalamus: A case report

Devos, Jana V.P.; Smit, Jasper V.; George, Erwin L.J.; Leue, Carsten; Ackermans, Linda; Temel, Yasin; Janssen, Marcus L.F.

doi:10.1016/j.brs.2023.08.016

Cited by 2 publications

(19 citation statements)

References 8 publications

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“…It has been shown that patients with cerebral infarction subsequently produce new neurons [ 55 ]. Advances in the field of neurosurgical intervention at the MGB give hope that a drug or stem-cell-based therapy might become available [ 24 ]. Insights into the neurogenesis and capacities of NSCs of the MGB represent a basis for this.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, it has recently been shown for the first time that the human MGB is surgically accessible. As part of deep brain stimulation to treat severe tinnitus, stereotactic surgery was performed on the human MGB [ 24 ]. The application of substances into the inner ear via a surgically inserted catheter already represents a promising translational approach for the treatment of cochlear hearing disorders [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Adult Neurogenesis of the Medial Geniculate Body: In Vitro and Molecular Genetic Analyses Reflect the Neural Stem Cell Capacity of the Rat Auditory Thalamus over Time

Engert,

Spahn,

Sommerer

et al. 2024

IJMS

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Neural stem cells (NSCs) have been recently identified in the neonatal rat medial geniculate body (MGB). NSCs are characterized by three cardinal features: mitotic self-renewal, formation of progenitors, and differentiation into all neuroectodermal cell lineages. NSCs and the molecular factors affecting them are particularly interesting, as they present a potential target for treating neurologically based hearing disorders. It is unclear whether an NSC niche exists in the rat MGB up to the adult stage and which neurogenic factors are essential during maturation. The rat MGB was examined on postnatal days 8, 12, and 16, and at the adult stadium. The cardinal features of NSCs were detected in MGB cells of all age groups examined by neurosphere, passage, and differentiation assays. In addition, real-time quantitative polymerase chain reaction arrays were used to compare the mRNA levels of 84 genes relevant to NSCs and neurogenesis. In summary, cells of the MGB display the cardinal features of NSCs up to the adult stage with a decreasing NSC potential over time. Neurogenic factors with high importance for MGB neurogenesis were identified on the mRNA level. These findings should contribute to a better understanding of MGB neurogenesis and its regenerative capacity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adult Neurogenesis of the Medial Geniculate Body: In Vitro and Molecular Genetic Analyses Reflect the Neural Stem Cell Capacity of the Rat Auditory Thalamus over Time

Engert,

Spahn,

Sommerer

et al. 2024

IJMS

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“…Likewise, TQ is a questionnaire defined by the Devos et al study as classifying "the patient according to increasing degree of severity of the complaints: mild (up to 30 points), moderate (31-46 points), severe (47-59 points), or very severe (60-84 points)." [21,22]. Neither Dijkstra et al [18] nor Devos et al [21] specified the primary and/or secondary outcomes in their respective studies [18,21], so TQ and THI were included as an additional outcome in the current study in order to facilitate direct comparison between these results and those of Cheung et al [19].…”

Section: Primary Outcomesmentioning

confidence: 95%

“…[21,22]. Neither Dijkstra et al [18] nor Devos et al [21] specified the primary and/or secondary outcomes in their respective studies [18,21], so TQ and THI were included as an additional outcome in the current study in order to facilitate direct comparison between these results and those of Cheung et al [19]. However, defining these as a primary or secondary outcome was intentionally avoided.…”

Section: Primary Outcomesmentioning

confidence: 96%

“…Two papers (Cheung et al [19] and Dijkstra et al [18]) used Tinnitus Handicap Inventory (THI) [20] as an additional outcome measure, while Devos et al [21] used Tinnitus Questionnaire (TQ) [22]. Based on previous work using objective measures to quantify tinnitus handicap, there is excellent correlation between the THI and TQ, suggesting that they assess a similar tinnitus-related construct [23].…”

Section: Primary Outcomesmentioning

confidence: 99%

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Deep Brain Stimulation for Primary Refractory Tinnitus: A Systematic Review

Basner,

Smit,

Zeitler

et al. 2024

Brain Sciences

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Background: tinnitus is a common and often debilitating condition with limited evidence-based treatment options. Deep brain stimulation (DBS) is an approved treatment modality for certain neurological conditions; its experimental use as a treatment modality for severe tinnitus is novel and beginning to show promise. This systematic review focuses on the current evidence for the safety and efficacy of DBS for treatment of refractory tinnitus. Methods: a systematic search in PubMed and EMBASE was performed to identify peer-reviewed studies on DBS of non-cortical structures for the primary indication of tinnitus treatment. Three studies were identified as meeting these criteria, one of which had two related sub-studies. Results: seven patients with available data who underwent DBS for tinnitus were identified. DBS targets included nucleus accumbens (NAc), ventral anterior limb of the internal capsule (vALIC), caudate nucleus, and the medial geniculate body (MGB) of the thalamus. All studies used the Tinnitus Functional Index (TFI) as a primary outcome measure. DBS of the caudate was most commonly reported (n = 5), with a mean TFI improvement of 23.3 points. Only one subject underwent DBS targeting the NAc/vALIC (extrapolated TFI improvement 46.8) and one subject underwent DBS targeting the MGB (TFI improvement 59 points). Conclusions: DBS is a promising treatment option for refractory subjective tinnitus, with early data, from small patient cohorts in multiple studies, suggesting its safety and efficacy. Further studies with a larger patient population are needed to support this safety and efficacy before implementing this treatment to daily practice.

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Effective treatment of refractory tinnitus by bilateral deep brain stimulation of the medial geniculate body of the thalamus: A case report

Cited by 2 publications

References 8 publications

Adult Neurogenesis of the Medial Geniculate Body: In Vitro and Molecular Genetic Analyses Reflect the Neural Stem Cell Capacity of the Rat Auditory Thalamus over Time

Adult Neurogenesis of the Medial Geniculate Body: In Vitro and Molecular Genetic Analyses Reflect the Neural Stem Cell Capacity of the Rat Auditory Thalamus over Time

Deep Brain Stimulation for Primary Refractory Tinnitus: A Systematic Review

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