Effective Stimulation of Cardiac Contractility and Myocardial Metabolism by Impromidine and Dimaprit—Two New H2-Agonistic Compounds—In the Surviving, Catecholamine-Insensitive Myocardium After Coronary Occlusion

Impromidine is a partial histamine H2‐receptor agonist on human ventricular myocardium

“…In that system however, despite the low maximum response, impromidine was substantially, approximately 100 fold, more potent than histamine. The presence of histamine H2-receptors in human myocardium associated with positive inotropic activity (Eckel et al, 1982), has prompted the proposal that H2-receptor antagonists including impromidine might have a place in the treatment of severe cardiac failure (Baumann et al, 1982). The present studies provide further evidence supporting the possible utility of impromidine in severe cardiac failure by demonstrating that this agonist can elicit a positive inotropic response in human ventricular myocardium.…”

Beneficial Effects of Defibrotide against Myocardial Ischemia and Decline of β-Adrenoceptor Function in the Rabbit

“…The functional significance of these changes is not sufficiently understood. However, since p-blocking agents, reserpine and PGIi have been demonstrated to reduce infarct size and preserve cardiac P-adrenoceptor activation [5][6][7][8][9][10][11][12], an interaction be tween excessive circulating catecholamines and increased prostaglandin generation should be of considerable importance in the local modifications following a prolonged ischemic event. The present study in the rab bit suggests that there is a similar pattern of myocardial modifications 3 days after coro nary ligations to that in the guinea pig.…”

“…Male albino rabbits weighing 2.5-3.5 kg were anes thetized with 30 mg/kg of sodium pentobarbital given intravenously and, following the procedure described by Baumann et al [6], myocardial infarction was pro duced by ligating the left anterior descending coronary artery. The hearts of the surviving animals were re moved 3 days after coronary ligation and perfused in order to study their functional condition.…”

Congestive heart failure secondary to myocardial infarction: Abnormalities in rat cardiac sarcolemma*1

“…General characteristics of experimental rats 4, I and 16 weeks after induction of myocardiaì infarction.…”

“…Although Th'is study was critjc'ized wìth respect to the signifìcance of the measured Ca2*-transport activity as welì as the role of a sancolemmal-bound phospholamban in this process (163); some investigators failed to reproduce these nesults (164). Although Since the sympathetic reguìation of cardiac contractility ìs crucial 'in adjusting blood flow to meet the metabol'ic requirements of the body, considerable effort has been d'irected at eluc'idating the status of the cardiac sarcolemmal ß1-adrenoceptor and assocjated protein systems in experimental and cl inical heart f ai lure (10,11,(13)(14)(15)(16). A rev'iew of earìy studies which focussed on the adenyìate cyclase activity from hearts of different strains of cardiomyopathic hamsters, rabbits with bacterial endocardit'is and aortic constriction, and of rats with substrate-lack, Ca2*-lack, or observed that th'is actjvity was decreased, and that thìs depression was assocjated with the degree of failure in some experiments (i).…”