Effective, Single-Dose Treatment of Procine Cysticercosis with Oxfendazole

Gonzales, Armando; Garcı́a, Héctor H.; Gilman, Robert H.; Gavidia, César; Tsang, Victor C. W.; Bernal, Teresa; Falcón, Néstor; Romero, Martha; López-Urbina, María T.

doi:10.4269/ajtmh.1996.54.391

Cited by 107 publications

(83 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The age of the pigs was established by asking the owner and corroborated using conventional teeth-eruption indicators in young animals. [39][40][41] At the same time, a 5-mL blood sample was taken from the pig's cava vein using vacuum tubes. Samples were processed as described above for human serum.…”

Section: Methodsmentioning

confidence: 99%

Hyperendemic Human and Porcine Taenia Solium Infection in Perú

Garcı́a¹,

Gilman²,

González³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

Self Cite

147

113

View full text Add to dashboard Cite

Abstract. The prevalence and characteristics of human taeniasis/cysticercosis and porcine cysticercosis were assessed in an endemic area of the Peruvian highlands. Individuals from 10 communities had stool examinations (N ‫ס‬ 2,951) and serologic testing for Taenia solium antibodies (N ‫ס‬ 2,583). The total porcine population present (N ‫ס‬ 703) was also examined by serology. Cysticercosis is hyperendemic in this area and is associated with an important number of seizure cases. Human seroprevalence by village ranged from 7.1-26.9% (mean, 13.9%). Seroprevalence was higher among individuals with a history of seizures but not in those reporting a history of headache or intestinal taeniasis. Prevalence of taeniasis ranged from 0-6.7% (median, 2.5%). Coproantigen detection found 2.4 times more taeniasis cases than did microscopy (direct and after concentration). Age distribution for taeniasis showed a peak at younger ages than for seroprevalence. Porcine seroprevalence ranged from 42-75%. Random effects logistic regression models for human seropositivity demonstrated both in-house clustering of cases and a large increase in risk associated with a tapeworm carrier in the house. Besides confirming the close relationship between taeniasis and cysticercosis cases, this large-scale field study demonstrated early age of tapeworm and cysticercosis infections in humans, and short duration of taeniasis infections.

show abstract

Section: Methodsmentioning

confidence: 99%

Hyperendemic Human and Porcine Taenia Solium Infection in Perú

Garcı́a¹,

Gilman²,

González³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

Self Cite

147

113

View full text Add to dashboard Cite

show abstract

“…Gonzales et al (1996) examined the effect of the drug on the tissue stage of tapeworm infections and found that a single dose of 30 mg/kg of body weight of oxfendazole in pigs completely eliminated all tissue cysts of Taenia solium, a medically important human tapeworm. Nevertheless, hydatid cysts are much larger than and structurally different from the cysts of cysticercosis, suggesting the possible use of oxfendazole for the treatment of hydatid disease.…”

Section: Treatment Of Echinococcosis In Dogs With Reference To Human mentioning

confidence: 99%

Incidence and the history of Echinococcus granulosus infection in dogs within the past few decades in Libya: A review

Mohamed¹,

Wafa²,

Kawther³

et al. 2017

J. Vet. Med. Anim. Health

View full text Add to dashboard Cite

Echinococcus granulosus is a tiny tapeworm that parasitizes the small intestine of canids, mainly dogs, which act as definitive hosts for the parasite. Infected dogs are the main source of infection to humans and livestock which act as intermediate hosts resulting in hydatid disease condition. E. granulosus is widely distributed in many parts of the world, and is very common in North African countries. In Libya, the rate of infection with echinococcosis in dogs was reported to be lower than 7 to 80% in stray dogs, 34.8 to 60% in sheep/guard dogs and 7.7 to 21.6% in farm/house dogs. This data fulfills the world health organization (WHO) criteria and suggests that the incidence of infection with echinococcosis/ hydatidosis in some parts of the country can be reaching the level of hyper endemic. Diagnosis of echinococcosis in infected dogs can be performed by isolating the parasite from their faeces or from the contents of their small intestine after necropsy. Recent developments in immunodiagnostic assays for echinococcosis in dogs have been described. Public health and risk factors as well as ways of hydatid disease treatment and various control strategies, including the use of veterinary vaccines, have also been discussed.

show abstract

“…Therefore, alternative measures for reduction of transmission are being developed, such as health education, mass chemotherapy in humans and pigs, and vaccination of pigs (Sarti et al, 1997;Garcia et al, 2007). Infected pigs treated with a single-dose of 30 mg/kg of oxfendazole became refractory to re-infection 3 months later (Gonzalez et al, 1996(Gonzalez et al, , 1997(Gonzalez et al, , 1998. Another approach initiated by different research groups is vaccination of pigs aiming at interrupting the parasite's life-cycle by preventing pigs from acquiring the larval stage (Nascimento et al, 1995;Sciutto et al, 1995;Flisser and Lightowlers, 2001;Flisser et al, 2004;Gonzalez et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Serological responses in porcine cysticercosis: A link with the parasitological outcome of infection

Deckers

Kanobana

et al. 2008

International Journal for Parasitology

View full text Add to dashboard Cite

An oral infection model with Taenia solium whole proglottids was used to study host-parasite relationships and the mechanisms underlying resistance to infection in pigs. In addition, an attempt was made to link the parasitological findings to serological data. Groups of six piglets aged 1, 3 and 5 months were infected and slaughtered 3 months p.i. Circulating antibody and antigen levels were monitored weekly. At autopsy total cyst counts were performed. Although the detailed carcass dissection at necropsy revealed a high variation in the number of cysts, the trend was that the number of viable cysts decreased with the age at which the animals were infected. The kinetics of the antigen levels throughout the course of the infection differed markedly between the three age groups of the experimental infection model. In the younger animals, a fast increase in titres of circulating antigen was observed in most animals, reaching a plateau as early as 2 weeks p.i. Besides its faster increase, antigen levels in pigs infected at younger ages also reached higher levels than in older animals and were associated with weaker antibody responses. Results also demonstrated that a relationship exists between the number of cysts and the titre of circulating antigen. This is promising in view of the development of an assay to quantify the progress of an active T. solium infection and would be a useful tool in epidemiological studies to assess the infection burden and the risk of transmission of the disease. The use of specific antibody-detection assays combined with circulating antigen detection could improve our understanding of this relationship. Ó

show abstract

Effective, Single-Dose Treatment of Procine Cysticercosis with Oxfendazole

Cited by 107 publications

References 0 publications

Hyperendemic Human and Porcine Taenia Solium Infection in Perú

Hyperendemic Human and Porcine Taenia Solium Infection in Perú

Incidence and the history of Echinococcus granulosus infection in dogs within the past few decades in Libya: A review

Serological responses in porcine cysticercosis: A link with the parasitological outcome of infection

Contact Info

Product

Resources

About