Effective replacement of cetyltrimethylammonium bromide (CTAB) by mercaptoalkanoic acids on gold nanorod (AuNR) surfaces in aqueous solutions

Caño, Rafael Del; Gisbert-González, José M.; González-Rodrı́guez, J.G.; Sánchez-Obrero, Guadalupe; Madueño, Rafael; Blázquez, Manuel; Pineda, Teresa

doi:10.1039/c9nr09137h

Cited by 46 publications

(23 citation statements)

References 70 publications

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“…It is a well-known strong interaction 44,45 , which has been used, for instance, to control the morphology and shape of gold nano-structures [45][46][47][48][49] . A special feature of the CTAB-gold interaction, rst proposed by El-Sayed et al 45 and con rmed by numerous subsequent studies, is the formation of an adsorbed CTAB double layer on the gold surface 45,50,51 . The proposed structure of that bilayer is the following (Fig.…”

Section: The Relevant Interactions In the Gox-ctab-gold Systemmentioning

confidence: 87%

Glucose oxidase converted into a general sugar-oxidase

Baruch-Shpigler

Avnir

2022

Preprint

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Entrapment of glucose oxidase (GOx) within metallic gold converts this widely used enzyme into a general saccharide oxidase. The following sugar molecules were oxidized by the entrapped enzyme (in addition to D-glucose): L-glucose, fructose, xylose,, glucose-6-phosphate, sucrose, lactose, methylglucoside, and the tri-saccharide raffinose. None of these sugars except raffinose has a natural specific oxidase. The origin of this generalization of activity is attributed to the strong protein-gold 3D interactions and to the strong interactions of co-entrapped cetyltrimethylammonium bromide (CTAB) with gold on one hand, and with the protein on the other hand. It is proposed that these interactions induce conformational changes in the channel leading to the active site, which is located at the interface between the two units of the dimeric GOx protein. The observations are compatible with affecting the specific conformation change of pulling apart and opening this gate-keeper, rendering the active site accessible to a variety of substrates. In addition to converting a common enzyme to an oxidase for common sugars which lack it, the entrapment methodology was found to be beneficial in increasing the thermal stability of GOx up to 100 oC and in allowing its convenient recyclability, two features of practical importance.

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Section: The Relevant Interactions In the Gox-ctab-gold Systemmentioning

confidence: 87%

Glucose oxidase converted into a general sugar-oxidase

Baruch-Shpigler

Avnir

2022

Preprint

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“…It is believed that effective biopolymer protection of nanoparticles should prevent the aggregation process via electrostatic or steric repulsion [10][11][12]. However, the 10:1 ratio result showed a different outcome as they are less stable in PBS (pH 7.4).…”

Section: Stability Of Gelatin@au-nrs In Biological Mediamentioning

confidence: 99%

“…However, studies have shown that it is one major cause of AuNRs toxicity [6][7][8][9]. Therefore, it is essential to find biocompatible, non-toxic, and stable surface modifying agents to passivate Au-NRs and reduce their toxicity whilst maintaining their optical properties [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of NIR-II Absorbing Gelatin Stabilized Gold Nanorods and Its Photothermal Therapy Application against Fibroblast Histiocytoma Cells

et al. 2021

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The excellent photothermal properties of gold nanorods (Au-NRs) make them one of the most researched plasmonic photothermal nanomaterials. However, their biological applications have been hampered greatly due to surfactant-induced cytotoxicity. We herein report a simple synthesis of highly biocompatible gelatin stabilized Au-NRs (gelatin@Au-NRs) to address this issue. The optical and structural properties of the as-synthesized gelatin@Au-NRs were investigated by Zetasizer, Ultraviolet-Visible-Near Infrared (UV-Vis-NIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), and Fourier transform infrared spectroscopy (FTIR). The as-synthesized gelatin@Au-NRs were highly crystalline and rod-like in shape with an average length and diameter of 66.2 ± 2.3 nm and 10 ± 1.6 nm, respectively. The as-synthesized gelatin@Au-NRs showed high stability in common biological media (phosphate buffer saline and Dulbecco’s Modified Eagle’s Medium) compared to CTAB capped Au-NRs. Similarly, the gelatin@Au-NRs showed an improved heat production and outstanding cell viability against two different cancer cell lines; KM-Luc/GFP (mouse fibroblast histiocytoma cell line) and FM3A-Luc (breast carcinoma cell line) compared to CTAB capped Au-NRs and PEG@Au-NRs. An in vitro photothermal therapy study against KM-Luc/GFP showed that gelatin@Au-NRs effectively destroys the cancer cells.

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“…Cetyltrimethylammonium bromide (CTAB) is the most commonly used surfactant and can form rod-shaped micelles in solution, which can effectively control the directional growth of anisotropic nanomaterials and promote the formation of NRs. In this mode, the CTAB acts as both a template and coating agent, facilitating mass production of NRs and nanowires [57,58]. Khanal et al developed a reversible chemical process for tip selective one-dimensional growth and dissolution of AuNRs, which can be continued with additional supply of Au(I)/CTAB/ascorbic acid solution to produce extremely long Au nanowires [59] (Figure 3).…”

Section: Nanorods (Nrs)mentioning

confidence: 99%

Noble Metal Nanostructured Materials for Chemical and Biosensing Systems

et al. 2020

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Nanomaterials with unique physical and chemical properties have attracted extensive attention of scientific research and will play an increasingly important role in the future development of science and technology. With the gradual deepening of research, noble metal nanomaterials have been applied in the fields of new energy materials, photoelectric information storage, and nano-enhanced catalysis due to their unique optical, electrical and catalytic properties. Nanostructured materials formed by noble metal elements (Au, Ag, etc.) exhibit remarkable photoelectric properties, good stability and low biotoxicity, which received extensive attention in chemical and biological sensing field and achieved significant research progress. In this paper, the research on the synthesis, modification and sensing application of the existing noble metal nanomaterials is reviewed in detail, which provides a theoretical guidance for further research on the functional properties of such nanostructured materials and their applications of other nanofields.

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Effective replacement of cetyltrimethylammonium bromide (CTAB) by mercaptoalkanoic acids on gold nanorod (AuNR) surfaces in aqueous solutions

Abstract: The highly packed cetyltrimethylammonium bromide bilayer on the surface of gold nanorods synthesized by the seed-mediated procedure hampers the complete ligand exchange under experimental conditions that preserves the stability of the dispersions.

Cited by 46 publications

References 70 publications

Glucose oxidase converted into a general sugar-oxidase

Glucose oxidase converted into a general sugar-oxidase

Synthesis of NIR-II Absorbing Gelatin Stabilized Gold Nanorods and Its Photothermal Therapy Application against Fibroblast Histiocytoma Cells

Noble Metal Nanostructured Materials for Chemical and Biosensing Systems

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