Effective Renal Plasma Flow (ERPF) of the Individual Kidney and Renal Venous Renin Activity (RVRA) Determined Simultaneously before and after the Administration of Dihydralazine in Renovascular Hypertension

Norman, Nils; Sundsfjord, Johan; Stiris, G

doi:10.1080/00365517509095733

Cited by 3 publications

(2 citation statements)

References 17 publications

(11 reference statements)

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“…The basis for ERPF calculation was the uptake by the kidney of l 3 I l OIH 11-21 min after the bolus injection (15,16). The ERPF referred to in the present study is the sum of that obtained from each kidney calculated as nil/min.…”

Section: C'ulculutionmentioning

confidence: 99%

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Decreased Renal Plasma Flow during Propranolol Treatment in Essential Hypertension

Falch¹,

Ödegaard²,

Norman³

1979

Journal of Internal Medicine

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ABSTRACT. The pharmacodynamic effect of propranolol (80 mg b.i.d.) on the renal and systemic circulation was studied after 1 and 8 months of treatment in 13 patients with essential hypertension, using non‐invasive radioisotope techniques. Effective renal plasma flow (ERPF) fell from (mean ± S.E.M.) 244±18 to 208±14 after 1 month and to 187±13 ml/min· m2 after 8 months of treatment. Concomitantly cardiac index (CI) fell from 3.24±0.15 to 2.62±0.11 and 2.75±0.10 1/min· m2, respectively. The coefficient of correlation between the decreases in ERPF and CI was 0.49. Mean arterial blood pressure decreased from 138±5 to 118±5 and 116±4 mmHg, respectively. Left ventricular work was reduced by 30.2 and 27%, while peripheral resistance was unchanged. Total plasma volume was increased from 19.3±0.5 to 20.3±0.6 ml/cm after 1 month, but was within the same range as the control values after 8 months of treatment. Pulmonary plasma volume was unchanged, indicating that there was no pooling of plasma in the pulmonary circulation. The interventricular circulation time was increased from 6.9±0.4 s to 8.4±0.3 s and varied with the change in heart rate. It is concluded that the fall in ERPF might be explained by reduced cardiac output in addition to interference with the hemodynamic autoregulation in the kidney.

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Section: C'ulculutionmentioning

confidence: 99%

“…The individual kidney 13'1 orthoiodohippuran ("'I OIH) clearance, ERPF, was determined with a renographic technique as described previously (15,16).…”

Section: Renographymentioning

confidence: 99%

Decreased Renal Plasma Flow during Propranolol Treatment in Essential Hypertension

Falch¹,

Ödegaard²,

Norman³

1979

Journal of Internal Medicine

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Peripheral renal vascular disease in essential hypertension: Hemodynamic, angiographic, and endocrine assessment

Arlart

1984

Cardiovasc Intervent Radiol

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Renal hemodynamic (133Xe-washout) and angiographic studies were performed in 46 patients with essential hypertension to demonstrate a possible correlation between graded renal small vessel disease and changes in renal blood flow. In addition, influence of the effects of duration of hypertension, diastolic blood pressure values and renal vein renin activity on hemodynamic and arteriographic findings were evaluated. Our results demonstrate that in patients with accelerated or severe renal small vessel disease the mean and cortical renal blood flow is significantly reduced (P less than 0.001). Furthermore, renal arteriosclerosis becomes evident in patients with long-standing hypertension, high diastolic blood pressure values, and elevated renal vein renin levels. Correlations between renal blood flow and renal vein renin activity (r = 0.45) apparently are governed by severity of the renal arteriosclerosis.

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High-performance liquid chromatographic determination of dihydralazine in humand plasma

Waller¹,

Chasseaud²,

Taylor³

1979

Journal of Chromatography A

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Effective Renal Plasma Flow (ERPF) of the Individual Kidney and Renal Venous Renin Activity (RVRA) Determined Simultaneously before and after the Administration of Dihydralazine in Renovascular Hypertension

Cited by 3 publications

References 17 publications

Decreased Renal Plasma Flow during Propranolol Treatment in Essential Hypertension

Decreased Renal Plasma Flow during Propranolol Treatment in Essential Hypertension

Peripheral renal vascular disease in essential hypertension: Hemodynamic, angiographic, and endocrine assessment

High-performance liquid chromatographic determination of dihydralazine in humand plasma

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