Effective reduction of the acute toxicity of certain pharmacologic agents by use of synthetic ion exchange resins

Drug Therapy of Urinary Calculi and Prevention of Recurrence

“…It is theoretically possible for water soluble organic cations, vitamin precursors and drugs to be bound. Such effects have never been documented, either in animal experiments or in clinical practice (BECKER and SWIFT 1959;DOCK and FRANK 1950;WOLFF 1954). Care should be taken with digitalized patients, to whom the daily intake of 984 mg potassium may be a hazard.…”

“…Toxicologic studies and teratogenicity tests have failed to show any adverse effect of synthetic ion exchange resins on reproduction, growth, bone marrow maturation, endocrine histology or major organ function (BECKER and SWIFT 1959;FLANAGAN et al 1951;MCCHESNEY and McAuLIFF 1950).…”

Ion-exchange resins as drug delivery carriers

“…Purified ion‐exchange resins are insoluble and nontoxic. However, administration of large enough quantities of ion‐exchange resin may disturb the ion strength in the gastrointestinal fluids and cause harmful side effects 8, 9…”

Antitussive Medication in Asthma, Emphysema and Chronic Bronchitis

“…Becker and Szvift (2) showed that such resin complexes have a substantially lower toxicity than correspontl-ing soluble salts of the same drugs. Sensenbach and Hays (i) have shown that the combination of a variety of therapeutically useful drugs with certain ion exchange resins to form resin complexes is capable of producing a drug having a predictable rate of release in the gastro-intestinal tract through the mechanism of ion exchange.…”

“…Sensenbach and Hays (i) have shown that the combination of a variety of therapeutically useful drugs with certain ion exchange resins to form resin complexes is capable of producing a drug having a predictable rate of release in the gastro-intestinal tract through the mechanism of ion exchange. Becker and Szvift (2) showed that such resin complexes have a substantially lower toxicity than correspontl-ing soluble salts of the same drugs. Deeb and Beeker (3) showed that such resin complexes produce sustained blood levels in experimental animals.…”