Effective Production of Paclitaxel and the Related Taxanes in a Plant Cell Culture by<i> in situ</i> Extraction with Sequential Refreshment of Water-Immiscible 1-Butyl-1- methylpyrrolidinium Bis(trifluoromethanesulfonyl)imide
Daiki NAGATA,
Waka NISHIKAWA,
Yuka IZAKI
et al.
Abstract:We report here the sequential refreshment of a water-immiscible ionic liquid, 1-butyl-1-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (P14TFSI) enhanced the production amount of paclitaxel and the related taxanes with in situ extraction from an aqueous medium in a plant cell culture. The production amount of the taxanes with refreshment of 2.5 vol% P14TFSI twice every 2 days was three times greater than that without the refreshment and 600 times greater than that of control culture without P14TFSI. Th… Show more
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