Effective Probiotic Delivery: Current Trends and Future Perspectives

Ragavan, Mangala Lakshmi; Das, Nilanjana

doi:10.1016/b978-0-12-822909-5.00029-0

Cited by 2 publications

(1 citation statement)

References 171 publications

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“…62 Additionally, one gene encodes a choloylglycine hydrolase, an enzyme responsible for the hydrolysis of bile that disrupts the amide bond between the steroid nucleus of glycine and bile acids. 63 Furthermore, two genes encode inorganic pyrophosphatase, which impacts bile acid : CoA ligase activity. 64 The presence of these coding genes suggests that B. paralicheniformis HMPM220325 possesses the capacity to withstand the presence of bile salts within the gastrointestinal tract of the host.…”

Section: Discussionmentioning

confidence: 99%

Molecular identification and safety assessment of the potential probiotic strain Bacillus paralicheniformis HMPM220325 isolated from artisanal fruit dairy products

Liang,

Dai,

Yang

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Molecular identification and safety assessment of the potential probiotic strain Bacillus paralicheniformis HMPM220325 isolated from artisanal fruit dairy products

Liang,

Dai,

Yang

et al. 2024

Food Funct.

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Genomic analysis and functional properties of Lactobacillus johnsonii GJ231 isolated from healthy beagles

Zhao,

Li,

Zhang

et al. 2024

Front. Microbiol.

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Probiotics are one of the management tools to improve the host’s healthy microbiota. The positive effects of probiotics on host health are species-specific, so probiotics isolated from host’s own gut may be most beneficial. Many of the metabolites (e.g., short-chain fatty acids, bacteriocins, and hydrogen peroxide) produced by Lactobacillus johnsonii have specific inhibitory profiles against invading pathogens. In this study, we isolated L. johnsonii GJ231 from the intestinal tract of healthy female beagles. The genome size of 1.763 M encoded a total of 1,691 predicted genes. Many carbohydrate-active enzymes responsible for carbohydrate degradation and the production of short-chain fatty acids were also predicted. The metabolic profile of short-chain fatty acids in L. johnsonii GJ231 was determined using LC–MS/MS. The bacteriocin-producing gene bacteriocin (lactacin F) in L. johnsonii GJ231 was also predicted. In vitro, experiments demonstrated that GJ231 can thrive in weak acids, 0.3% bile salts, and artificial gastrointestinal fluid models. It was tolerant of to high temperatures up to 70°C, was non- hemolytic, inhibited pathogenic bacteria, and had a high antioxidant capacity. In vivo safety experiments conducted in mice revealed that oral administration of GJ231 not only had no toxic side effect but also increased their antioxidant capacity. In conclusion, combining the above test results, which collectively demonstrate that canine-derived L. johnsonii GJ231 was a non-pathogenic, acid-tolerant and bile-salt-tolerant probiotic strain that inhibits pathogenic bacteria and improves host antioxidant function. This may make it a promising candidate for the development of innovative functional foods for pets.

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Effective Probiotic Delivery: Current Trends and Future Perspectives

Cited by 2 publications

References 171 publications

Molecular identification and safety assessment of the potential probiotic strain Bacillus paralicheniformis HMPM220325 isolated from artisanal fruit dairy products

Molecular identification and safety assessment of the potential probiotic strain Bacillus paralicheniformis HMPM220325 isolated from artisanal fruit dairy products

Genomic analysis and functional properties of Lactobacillus johnsonii GJ231 isolated from healthy beagles

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