Effective prevention of lethal acute graft-versus-host disease by combined immunosuppressive therapy with prodigiosin and cyclosporine A

Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma

“…IFN-γ could signify the relationship with attenuated graft-versus-host-disease (GVHD). Allogenic spleen cells with bone marrow cells could induce GVHD in recipient mice by showing body weight loss and death within 9 days after transplantation [22]. However, CIK cells did not induce GVHD, even when injected with 10 times the amount of CIK cells compared to spleen cells [6].…”

“…Inc., Houston, TX, USA). Reverse transcription-polymerase chain reaction (RT-PCR) was performed to examine cytokine gene expressional changes [22]. The primer sequences used were as follows [23]: …”

Role of interleukin-2 regulated proteins in immunosuppression by the N-alkylated prodigiosin analogue

“…T cell selective immunosuppression by the members of prodigiosin family was first described by Nakamura et al [4]. Subsequent studies with different natural and synthetic prodigiosins have demonstrated their immunosuppressive activities in vitro and in vivo [5][6][7][8][9][10][11][12]. Prodigiosins do not target the secretion of IL-2 but are reported to inhibit the downstream signaling.…”

Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model

“…In addition, IFN-γ plays a pivotal role in attenuation of graft-versus-host disease (GVHD) [41]. Allogenic spleen cells with bone marrow cells induce GVHD in recipient mice, inducing body weight loss and death within 9 days after transplantation [42]. However, CIK cells do not induce GVHD, even when 10 times the amount of CIK cells are injected compared to spleen cells [41].…”