Effective Prediction of Preeclampsia by a Combined Ratio of Angiogenesis-Related Factors

Abstract

II.

Angiogenic balance and diagnosis of pre-eclampsia: selecting the right VEGF receptor

“…This is contrary to what has been noted in almost all published reports that show reduced VEGF levels. [2][3][4][5] In our investigations, we have consistently found circulating VEGF levels to be undetectable in PE/eclampsia. The basis for this reduction is also well defined.…”

“…A large number of studies, both experimental and human, have shown consistent increases in sFlt-1 in PE, and have suggested using it either alone or in combination with serum PlGF (as sFlt-1:PlGF ratio) to differentiate PE from other hypertensive disorders of pregnancy. 2,5,6 Several studies have shown that these possess superior discriminatory ability than that shown by the authors. 5,7,8 In a comparative study of pre-eclamptic and normotensive pregnancies, we found the circulating sFlt-1 to be significantly increased in PE compared with normotensive pregnancies, 9 whereas the mean PlGF levels were reduced.…”

“…2,5,6 Several studies have shown that these possess superior discriminatory ability than that shown by the authors. 5,7,8 In a comparative study of pre-eclamptic and normotensive pregnancies, we found the circulating sFlt-1 to be significantly increased in PE compared with normotensive pregnancies, 9 whereas the mean PlGF levels were reduced. Receiver operating characteristic curve analysis showed that sFlt-1 and sFlt-1:PlGF ratio cutoffs of 15.7 and 92.2 ng ml À1 , respectively, were able to distinguish PE from normotensive pregnancies with 100% sensitivity and specificity.…”

Angiogenic balance and diagnosis of pre-eclampsia: selecting the right VEGF receptor

“…The statement made by Jha et al is true that a large number of studies, both experimental and human 9,[15][16][17] have shown consistent increase in sFlt-1 (sVEGFR-1) in PE patients. Similar observations were also observed by us in our previous study 18 where we reported that the serum levels of sVEGFR-1 were positively increased (Po0.0001) in patients with PE at different gestational intervals as compared with the healthy pregnant women.…”

732: First trimester PAPP-A levels correlate with sFlt-1 levels longitudinally in pregnant women with and without preeclampsia

“…In addition, the relationship of first trimester PAPP-A to serial levels of placental growth factor (PlGF) and serial ratios of sFlt-1 to PlGF were also explored, as studies have shown that PlGF is significantly lower in preeclampsia [9] and the ratio of sFlt-1/PlGF is also significantly elevated in preeclampsia [10,11], prior to the onset of clinical signs.…”