Effective palliation without normal tissue toxicity using low-dose ultrafractionated re-irradiation for tumor recurrence after radical or adjuvant radiotherapy

Second re-irradiation: a narrative review of the available clinical data

“…It has been shown that prospective single-arm and randomized trials are feasible in the re-irradiation setting [23,[35][36][37][38][39]. Such trials employing highly conformal techniques are also warranted to strengthen the evidence for second re-irradiations, and might include several different strategies to improve the therapeutic ratio [40][41][42][43]. With the development of cumulative dose constraints and practice recommendations regarding suitable minimum time intervals, reluctance to retreat is expected to diminish, and an increasing number of patients will thus be able to benefit from repeated courses of radiotherapy.…”

Low dose hypersensitivity following in vitro cell irradiation with charged particles: Is the mechanism the same as with X-ray radiation?

“…Palliative low dose ultrafractionated therapy (LDUF RT) was successfully used with selected patients showing tumor recurrence in a previously irradiated area (Pulkkanen et al 2007). Patients were treated with three fractions of 0.5-0.66 Gy 4 h apart daily.…”