Effective neutralization of chemical warfare agents (HD, VX) by Me-DABCOF: a small molecule with dual action

Karton-Lifshin, Naama; Katalan, Shahaf; Columbus, Ishay; Chen, Ravit; Yehezkel, Lea; Madmon, Moran; Dagan, S.; Elias, Shlomi; Fridkin, G.; Zafrani, Yossi

doi:10.1039/c9cc07011g

Cited by 12 publications

(11 citation statements)

References 36 publications

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“…Chemical warfare agents (CWAs), which have been applied to World War I, the Tokyo subway, and the Syria Internal War, are one of the most terrible weapons enabling to cause mass murders by inducing oxygen deficiency, blisters, and interruption of the active nerve cell to people. − Because of the lethal properties of CWAs, the usage of them has been strictly prohibited by the Chemical Weapons Convention since 1997, and many efforts have been taken to get rid of stored CWAs. However, current decomposition methods including neutralization and incineration are now suffering from the detrimental issues of high energy consumption, secondary pollutants, and chemical wastes. − To overcome this, many researchers have contributed to developing new methods with catalysts using oxidation and/or hydrolysis reactions. , Reactive polymers, organophosphorus hydrolase enzymes, and metal oxides such as SnO 2 , WO 3 , In 2 O 3 , and MnO 2 are the most popular catalysts for decomposing CWAs, which are still showing insufficient catalytic activity (half-lives > 1.8 h) to meet the desired catalytic performance. − To this end, the development of new materials for the efficient decomposition of CWAs remains a crucial challenge.…”

Section: Introductionmentioning

confidence: 99%

Continuous Flow Composite Membrane Catalysts for Efficient Decomposition of Chemical Warfare Agent Simulants

Seo

Cho

Lee

et al. 2020

ACS Appl. Mater. Interfaces

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Continuous and safe decomposition of chemical warfare agents (CWAs) is a critical requirement to protect both soldiers and citizens and to eliminate the stockpiles after the cold war. The Zr-based metal−organic framework (Zr-MOF) has been known as the most effective catalyst for decomposing CWAs, especially the most fatal nerve agents, however, its low processability due to the powder form limits its expansion to actual military applications. To this end, the composite membrane catalysts (CMCs) comprising the Zr-MOF (UiO-66 catalyst) and nylon 6 nanofiber (porous supporter) are developed by the simple integration of electrospray and electrospinning, resulting in selective immobilization of UiO-66 on the surface of the nylon 6 nanofibers. These strategical benefits of CMCs gave super catalytic durability including recyclability over five times without decreasing the catalytic activity for the decomposition of methyl paraoxon (MPO), a simulant of the nerve agent, in the presence of N-ethylmorpholine (N-EM), which was not achieved in the original particulate UiO-66. Because of the excellent physical and chemical stabilities of CMCs, the CMC with 56 wt % of UiO-66 (CMC56) decomposed 198 g of MPO within an hour in the continuous flow system with a flow rate of 21.6 mL h −1 . This study highlights the important strategies in designing the feasible membrane-type catalysts with superior catalytic activity and robust durability for decomposing CWAs in the continuous flow system.

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Section: Introductionmentioning

confidence: 99%

Continuous Flow Composite Membrane Catalysts for Efficient Decomposition of Chemical Warfare Agent Simulants

Seo

Cho

Lee

et al. 2020

ACS Appl. Mater. Interfaces

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“…In recent years, an increasing number of studies have been conducted on reactive solids and their ability to destroy CWAs. Systems based on various materials like activated carbon, zeolites, POMs, − MOFs, ,,,− inorganic oxides such as alumina (Al 2 O 3 ), − silica (SiO 2 ), and titania (TiO 2 ), − and zirconium compounds − were introduced to the field of CWA decontamination. Due to their high surface area and unique physical and chemical properties that include a large number of basic and acidic sites, these systems can significantly accelerate hydrolysis reactions.…”

Section: Introductionmentioning

confidence: 99%

Efficient Decontamination of HD by an Electrophilic Iodine/Carboxylate Composite as an Active Sorbent

2022

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The development of new and efficient decontamination methods has become more relevant in recent years, especially with regard to solid-based decontamination and detoxification systems. The majority of powders used today are dealing with the physical adsorption of chemical warfare agents (CWAs) and their removal from sites without actively destroying them. In this work, we have designed and developed an active solid composite matrix combining organic carboxylate salts and N -iodosuccinimide (NIS) for HD decontamination via oxidation. All the reactions and mechanistic studies for the sorption and degradation of CWAs were conducted using direct polarization and cross polarization solid-state magic-angle spinning nuclear magnetic resonance techniques. Performance toward the sorption and detoxification of HD was tested, exhibiting oxidation within minutes in a mild and selective manner to the nontoxic sulfoxide derivative followed by visible formation of iodine. The results indicate that carboxylate moieties in the matrix are important for stabilizing the positively charged sulfonium ion intermediate and for supplying oxygen for hydrolysis in a water-deficient environment. The NaOBz/NIS composite was shown to be the most efficient in sorbing and converting the water-insoluble agent HD to its nontoxic, water-soluble sulfoxide, which could then be removed from the site with mere water, resulting in less environmental damage and quick remediation.

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“…Recently, a group from Israel reported two interesting methods leading to the abatement of both HD and VX agents: either mediated by H 2 O/I + (from NIS) 11 or with the reagent Me-DABCOF. 12 In both cases, the protocols release stoichiometric amounts of organic byproducts to be further disposed along with the transformed CWA. Moreover, such protocols might be difficult to upscale.…”

Section: Introductionmentioning

confidence: 99%

Flow neutralisation of sulfur-containing chemical warfare agents with Oxone: packed bed vs. aqueous solution

et al. 2021

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Effective neutralization of chemical warfare agents (HD, VX) by Me-DABCOF: a small molecule with dual action

Abstract: Me-DABCOF, a mild universal, non-corrosive, water-soluble decontamination agent that effectively neutralizes chemical warfare agents (HD, VX).

Cited by 12 publications

References 36 publications

Continuous Flow Composite Membrane Catalysts for Efficient Decomposition of Chemical Warfare Agent Simulants

Continuous Flow Composite Membrane Catalysts for Efficient Decomposition of Chemical Warfare Agent Simulants

Efficient Decontamination of HD by an Electrophilic Iodine/Carboxylate Composite as an Active Sorbent

Flow neutralisation of sulfur-containing chemical warfare agents with Oxone: packed bed vs. aqueous solution

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