Effective Medicinal Plants in the Treatment of the Cyclic Mastalgia (Breast Pain): A Review

Niazi, Azin; Rahimi, Vafa Baradaran; Hatami, Hooman; Shirazinia, Reza; Esmailzadeh-dizaji, Reza; Askari, Nafiseh; Askari, Vahid Reza

doi:10.3831/kpi.2019.22.017

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…Mastitis is common during lactation and concerns an inflammatory condition, in which the breast is swollen and wedgeshaped with increased local temperature and pain, whether or not resulting from infection 14,15 . Mastalgia -the clinical name for breast pain -is the most common benign change in the female reproductive cycle and occurs mainly in the pre-menstrual phase 16 . Papillary effusion or papillary discharge is the exit of secretion through the mammary papilla in women who are not lactating and/or pregnant.…”

Section: Discussionmentioning

confidence: 99%

Investigation of breast pathologies in medical students and their families

Sousa,

Barbosa,

Santos

et al. 2023

Mastology

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Introduction: Breast diseases include benign and malignant pathologies. However, during the differential diagnosis, it is important to distinguish benign pathology, precursor lesions of breast cancer, and malignant breast neoplasm. We believe that research among medical students on the prevalence of breast pathologies in this population and their families is important in addition to identifying patients at high familial risk for breast and/or ovarian cancer and awakening the interest of other medical students in this topic. The objective of this study was to analyze the prevalence of benign and malignant breast pathologies among medical students and their families. Methods: This is a quantitative analytical cross-sectional study. Female medical students over 18 years old were included in the study. Data collection was carried out using an online questionnaire. It was approved by the Research Ethics Committee under CAAE Protocol No. 51338121.0.0000.5515, and each participant consented through the free and informed consent form (TCLE). Results: A total of 303 medical students responded to the questionnaire and were included in the study. Around 13.5% of participants reported having had some breast pathology, 76.2% of which were cases of breast lumps. The average age of participants was 22.9 years (ranging between 18 and 53 years). The average age of family members at diagnosis (a sample of 69 women) was 57.1 years (ranging between 29 and 84 years). There was an association between the prevalence of breast pathologies and a family history of breast cancer (OR=1.712 [0.818; 3.585]). Conclusion: From the results, it appears that 13.5% of the participants had already been diagnosed with breast pathology, and 20.8% of these reported a family history of breast cancer. In this way, we can affirm the contribution of the study in the evaluation of screening criteria for breast and neoplasms and thus increase the detection rate and carry out early therapy.

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Section: Discussionmentioning

confidence: 99%

Investigation of breast pathologies in medical students and their families

Sousa,

Barbosa,

Santos

et al. 2023

Mastology

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“…In addition, the dopaminergic effects of VAC are supposed to be beneficial in treating cyclic mastalgia [ 8 ]. In 2019, Niazi et al related this effect to antioxidant compounds with anti-inflammatory and analgesic effects [ 18 ]. Due to VAC’s phytoestrogen effect, it can alleviate menopausal symptoms and improve the quality of life of women [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety

et al. 2022

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Objectives: Herbal medicine is a worldwide health topic. Vitex agnus-castus L. (VAC) is a popular plant used for gynecologic problems due to its hormonal effects. The aim of this study is to reveal VAC extract effect on fetus when this herb is used started from antenatal period or during pregnancy. Methods: Performed from starting day of January 2019 till February 2019, 48 rats were assigned in randomly divided eight-member six groups: control (C1), treated group with 365 mg/kg VAC from initiation of insemination (T1) and 30 days prior to pregnancy (T2), control that underwent caesarean section on 15 th day of gestational age (C2) and treated group with 365 mg/kg VAC from initiation of insemination (T3) and 30 days prior to pregnancy (T4) that underwent caesarean section. Weight, sex and number of fetuses, abortion and still birth rate and estradiol level were evaluated using t-test by SPSS software. Results: We showed increased weight among T1 group considering totally and sex-dependent which is significant (all p-value < 0.05). We also detected significantly decreased weight in T2 in total (p-value < 0.0001) and when considering female fetuses (0.043) but not males (0.17). Although the results showed slightly non-significant increased weight among fetuses of T3 (totally or based on the fetus sex) compared to the control group (C2), T4 group had statistically decreased weight compared to control group. Pregnancy rate and pregnancy outcome were affected by VAC usage. The time of VAC initiation also affected live birth and abortion rates. Conclusion: VAC extract may affect pregnancy rate, live birth rate, abortion and stillbirth rates. Its effect on the weight and the sex showed dual pattern depends on the time of initiation and pregnancy trimester of evaluation. Prescribing this medicinal plant for patients being prone to pregnancy should be with caution. Further study is recommended.

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“…Based on the scientifi c evidence, there are numerous alternative plant-based treatments for mastalgia (7,30). It has been reported that mastalgia can be healed by Vitex agnus-castus, Nigella sativa, Hypericum perforatum, Ginkgo biloba, Citrus sinensis, curcumin, and wheat germ (30). The goal of this study is to look at how V. agnus-castus is used to treat mastalgia and its mechanisms of action.…”

Section: Vac and Mastalgiamentioning

confidence: 99%

The mechanisms underlying the role of Vitex agnus-castus in mastalgia

ZEQIRI¹,

DERMAKU-SOPJANI²,

SOPJANI³

2022

BLL

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Medicinal plants exert therapeutic effects or have benefi cial healing functions on the human or animal body. Medicinal plants are widely used in traditional medicine as an interesting alternative and/or complementary to science-based medicine. Compared to chemical drugs, medicinal plants have a lower risk of side effects, are eco-friendly, and have cost-effective production. This encouraged researchers to extensively exploit them for their therapeutic use. One of the most well-known medicinal plants is Vitex agnus-castus L., which belongs to the Verbenaceae family. This shrub tree is mainly grown in tropical and sub-tropical regions. The parts of VAC, especially berries and leaves, contain essential oils, fl avonoids, and diterpenes. Many medical benefi ts of VAC have already been reported, including mastalgia, regulating menstrual cycles and premenstrual complaints, and infertility. Respiratory and cardiovascular effects are also reported. In this review, we will analyze and characterize the known roles of VAC in mastalgia, as well as the mechanism of action reported in in vitro and/or in vivo studies, and show the potential for alternative therapeutic uses in mastalgia, also known as breast pain (Fig. 2, Ref. 40).

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Effective Medicinal Plants in the Treatment of the Cyclic Mastalgia (Breast Pain): A Review

Cited by 8 publications

References 24 publications

Investigation of breast pathologies in medical students and their families

Investigation of breast pathologies in medical students and their families

Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety

The mechanisms underlying the role of Vitex agnus-castus in mastalgia

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