Effective lovastatin therapy in elderly hypercholesterolemic patients — an antioxidative impact?

Brosche, Thorolf; Kral, Christiane; Summa, Jörg-Dieter; Platt, D.

doi:10.1016/0167-4943(95)00694-x

Cited by 15 publications

(10 citation statements)

References 44 publications

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confidence: 75%

“…Preparation of red yeast rice following ancient methods by fermenting the fungal strain Monascus purpureus went on moist and sterile rice. The medicinal properties of red yeast rice were described by pharmacologists of the Ming Dynasty (1368-1644) as cited by Ma et al [1][2][3][4][5] It is concluded from the present evidence that Red yeast rice possess opportunities for development as new functional foods.6) Red yeast rice, or Hongqu in Chinese, is a typical product in Mingbei area of Fujian province, and a most well known product from Gutiang. 7) From ancient time to now, the method of production all over the countries including Taiwan, and Okinawa (Japan) has been originating from Gutiang and Pinnan counties of Fujian province.…”

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confidence: 82%

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The Quantification of Monacolin K in Some Red Yeast Rice from Fujian Province and the Comparison of the Other Product

et al. 2006

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Red yeast rice, a traditional Chinese medicine and food known for centuries to improve blood circulation and maintain taste and color in fish and meat. Preparation of red yeast rice following ancient methods by fermenting the fungal strain Monascus purpureus went on moist and sterile rice. The medicinal properties of red yeast rice were described by pharmacologists of the Ming Dynasty (1368-1644) as cited by Ma et al. [1][2][3][4][5] It is concluded from the present evidence that Red yeast rice possess opportunities for development as new functional foods.6) Red yeast rice, or Hongqu in Chinese, is a typical product in Mingbei area of Fujian province, and a most well known product from Gutiang. 7) From ancient time to now, the method of production all over the countries including Taiwan, and Okinawa (Japan) has been originating from Gutiang and Pinnan counties of Fujian province.7) The modern research has revealed that monacolin K has been proven to be a characteristic constituent of red yeast rice. 8) In this report, monacolin K was identified in red yeast rice of Fujian Province, using high-performance liquid chromatography with photodiode array detector and tandem mass spectrometry. All of these materials including raw material powder and finished products available from the different areas of Fujian province were quantified and the contents of monacolin K were calculated with reference of monacolin K commercially available as the standard. 9,10) ExperimentalChemicals, Reagents and Materials Methanol, HPLC grade; de-ionized water was obtained with an in-house Milli-Q water system (Millipore Inc., U.S.A.). Monacolin K standard was ordered from Sigma (MO, U.S.A.), nine batches of red yeast rice powder were kindly provided by a health food company in Fuzhou, commercial product from the other province of China.Equipment Liquid chromatography and mass spectrometry (LC/ PDA/MS) were carried out using a system equipped with Surveyor LC system (Thermo Finnigan, San Jose, U.S.A.) including quaternary pump, online degasser, column heater compart, autosampler and photodiode array detector, and a LCQ DECA XP MAX mass spectrometer (Thermo Finnigan, San Jose, U.S.A.) that consists of an ESI interface and an ion trap mass analyzer. The software for the control of the equipment, and the acquired and treatment of data is Xcalibur 1.3 workstation.The chemical fingerprints were conducted on the HPLC system of Waters 2695 Alliance (Milford, MA, U.S.A.), consisting of quaternary pump solvent management system, an on-line degasser and an autosampler. The raw data were detected by 2996 photo-diode array detector (PDA), and acquired and processed by Waters Empower chromatographic workstation loaded on a Compaq computer. Prior to each run, the HPLC-PDA system was allowed to warm up for nearly 30 min and the baseline was monitored until stable before the samples were injected.Sample Preparation About 0.3 g red yeast rice powder, accurately weighed, was transferred to a 10-ml tampon centrifuge tube. The preparations were extracted with...

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The Quantification of Monacolin K in Some Red Yeast Rice from Fujian Province and the Comparison of the Other Product

et al. 2006

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“…2005, 2007). Moreover, lovastatin treatment has been reported to increase PlsEtn levels in patients with hypercholesterolemia (Brosche et al. 1996) and to up‐regulate peroxisomal activity in keratinocytes (Williams et al.…”

Section: Discussionmentioning

confidence: 99%

Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin

Khan

Singh

2008

Journal of Neurochemistry

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In cerebral adrenoleukodystrophy (cALD), an accumulation of very long chain fatty acids stems from a defect of the peroxisomal ALD protein (ALDP) and results in the loss of myelin/ oligodendrocytes, induction of inflammatory disease and mental deterioration. In brain white matter of cALD patients, we observed not only increased levels of very long chain fatty acid but also reduced levels of plasmenylethanolamine (PlsEtn) and increased levels of reactive oxygen species (ROS). The loss of PlsEtn was greatest in the plaque area and lesser but significant at histologically normal-looking areas of the cALD brain. The reduction in PlsEtn was related to oxidative stress, as supported by increased levels of reactive lipid aldehydes (4-hydroxynonenal and acrolein) and deleterious oxidized proteins (protein carbonyl) in all areas of the cALD brain. This inverse relationship between the levels of PlsEtn and reactive oxygen species (ROS) was further supported in an in vitro study using gene-silencing for dihydroxyacetone phosphate-acyl transferase, a key enzyme for PlsEtn biosynthesis. Levels of PlsEtn were also found decreased in vitro following gene-silencing for the ALDP/ALDrelated protein. Furthermore, low levels of PlsEtn were detected in brain white matter of ALDP knock out (KO) mice. A treatment of ALDP KO mice with lovastatin increased PlsEtn levels in the brain. Further, in an in vitro study, lovastatin treatment of rat C6 glial cells increased PlsEtn biosynthesis and reduced the cytokine-induced ROS accumulation. In summary, this study reports that altered metabolism of PlsEtn and ROS in cALD may be corrected by lovastatin treatment.

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“…Lipid-lowering agents that inhibit HMG coenzyme A reductase are now prominent among the drugs of choice for treating hypercholesterolemia. It is another effective way to control cholesterol level with diet and food supplements [1]. Red yeast rice, (rice fermented with red yeast Monascus purpureus), was found to be a food product that has the ability of reducing blood-lipid levels in both animal models and in humans [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Identification and chemical profiling of monacolins in red yeast rice using high-performance liquid chromatography with photodiode array detector and mass spectrometry

Fang

Wang

et al. 2004

Journal of Pharmaceutical and Biomedical Analysis

125

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Effective lovastatin therapy in elderly hypercholesterolemic patients — an antioxidative impact?

Cited by 15 publications

References 44 publications

The Quantification of Monacolin K in Some Red Yeast Rice from Fujian Province and the Comparison of the Other Product

The Quantification of Monacolin K in Some Red Yeast Rice from Fujian Province and the Comparison of the Other Product

Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin

Identification and chemical profiling of monacolins in red yeast rice using high-performance liquid chromatography with photodiode array detector and mass spectrometry

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