Effective High-Accuracy Prediction of Protein Structures from Easily Obtainable Artificial Homologous Sequences by Structure-Stability-Based Selection
Jinle Tang,
Zhe Zhang,
Jian Zhan
et al.
Abstract:High-resolution protein structure determination by experimental techniques is notoriously costly and labor intensive. This problem is mostly solved with arrival of deep-learning-based computational prediction by AlphaFold2 but only for those proteins with enough naturally occurring homologous sequences. Here, we attempt to close the remaining gap by employing artificially generated, structure-stability-selected homologous sequences as an input for AlphaFold2. We showed that only one round of selection of deepl… Show more
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