Effective health care: management of head and neck cancers

Collins, Rob; Flynn, Allen J.; Melville, A; Richardson, Rachel; Eastwood, Alison

doi:10.1136/qshc.2005.013961

Cited by 19 publications

(17 citation statements)

References 67 publications

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“…The healthcare system should streamline the patients' course from clinical suspicion to diagnosis confirmation, surgical and/or oncologic treatment and functional rehabilitation 3 .…”

Section: Introductionmentioning

confidence: 99%

Difficulties in the surgical management of head and neck cancer patient

Sarafoleanu

Vuzitas

Manea

2017

Romanian Journal of Rhinology

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Malignancies of the upper aerodigestive tract are high morbidity bearing and life-threatening diseases, which require thorough care from diagnostic suspicion and confirmation to surgical and/or oncologic treatment and rehabilitation. Difficulties in managing head and neck cancers arise from delays in diagnosis and treatment caused by either patient-related factors or healthcare system-related factors. Tumor origin and stage determine whether surgical excision is feasible, the approach required for safe excision, the extent of functional and aesthetic sacrifice required to attain oncologic safety and the need for reconstructive surgery. A thorough and systematic preoperative risk versus benefits assessment to select potential surgical candidates and give realistic outcomes is important from both a medical and a legal point of view. Because tumors in the head and neck region frequently involve more than one system and sensory organ, potential loss of function from either the disease course, surgical or nonsurgical treatment should be taken into account form a quality of life perspective. Effective management of head and neck cancer patients requires the cooperation and combined effort of a multidisciplinary team of surgeons, physicians and other workers over a long period of time which, in the absence of a specialised head and neck cancer centre and guidelines, can lead to increased morbidity and mortality, and patient dissatisfaction.

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“…The healthcare system should streamline the patients' course from clinical suspicion to diagnosis confirmation, surgical and/or oncologic treatment and functional rehabilitation 3 .…”

Section: Introductionmentioning

confidence: 99%

Difficulties in the surgical management of head and neck cancer patient

Sarafoleanu

Vuzitas

Manea

2017

Romanian Journal of Rhinology

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“…Le but de cet examen est de supprimer toutes les dents situées dans les champs d'irradiation présentant un foyer infectieux ou pouvant en entraîner un. Les extractions dentaires sont relativement fré-quentes avant la radiothérapie puisqu'il a été montré que les patients présentant un cancer des voies aérodigestives supé-rieures ont habituellement un faible suivi bucco-dentaire et que 95 % d'entre eux nécessitent des soins bucco-dentaires avant le traitement de leur cancer [17,[73][74][75]. Les extractions dentaires doivent être les moins traumatisantes possibles car plus la cicatrisation est rapide, plus l'irradiation pourra commencer tôt.…”

Section: Discussionunclassified

“…L'ensemble de ces phénomènes peut compromettre l'ostéointégration des implants. Bien qu'elle ne fasse pas consensus, l'augmentation de la fréquence des échecs implantaires après irradiation [15][16][17] est communément admise [18]. L'absence de consensus porte essentiellement sur l'ostéointégration à la mandibule ; une augmentation de la fré-quence des échecs de l'ostéointégration dans les autres sites implantaires maxillo-faciaux et notamment au maxillaire est communément reconnue.…”

Section: Intérêt De L'implantologie Chez Le Patient Irradiéunclassified

Intérêt de l’utilisation de l’oxygénothérapie hyperbare en prévention de l’échec implantaire chez le patient irradié

Gunepin

Derache

Cathelinaud

et al. 2012

Med Buccale Chir Buccale

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“…The current standard treatment for head and neck cancer utilizes a multimodality approach, which includes surgery, in combination with radiotherapy and chemotherapy [1]. One of the most common side effects of radiotherapy treatment for head and neck cancer is dysfunction of the salivary glands [2].…”

Section: Introductionmentioning

confidence: 99%

Palliative Care for Salivary Gland Dysfunction Highlights the Need for Regenerative Therapies: A Review on Radiation and Salivary Gland Stem Cells

2014

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Radiotherapy remains the major course of treatment for Head and Neck cancer patients. A common consequence of radiation treatment is dysfunction of the salivary glands, which leads to a number of oral complications including xerostomia and dysphagia, for which there is no existent cure. Here, we briefly describe the current palliative treatments available for patients undergoing these conditions, such as oral lubricants, saliva substitutes, and saliva stimulants. None of these options achieves restoration of normal quality of life due to their limited effectiveness, and in some cases, adverse side effects of their own. Other therapies under development, such as acupuncture and electrostimulation have also yielded mixed results in clinical trials. Due to the ineffectiveness of palliative care to restore quality of life, it is reasonable to aim for the development of regenerative therapies that allow restoration of function of the salivary epithelium following radiation treatment. Adult stem cells are a necessary component of wound healing, and play important roles in preserving normal function of adult tissues. Thus, the present review mainly focuses on the effects of radiation on adult stem cells in a variety of tissues, which may be at play in the response of salivary glands to radiation treatment. This is of clinical importance because progenitor cells of the salivary glands have shown partial regenerative potential in mouse transplantation assays. Therefore, understanding how these progenitor cells are affected by radiation offers potential for development of new therapies for patients with xerostomia.

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Effective health care: management of head and neck cancers

Cited by 19 publications

References 67 publications

Difficulties in the surgical management of head and neck cancer patient

Difficulties in the surgical management of head and neck cancer patient

Intérêt de l’utilisation de l’oxygénothérapie hyperbare en prévention de l’échec implantaire chez le patient irradié

Palliative Care for Salivary Gland Dysfunction Highlights the Need for Regenerative Therapies: A Review on Radiation and Salivary Gland Stem Cells

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