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Abbreviations : GLP-1: glucagon-like peptide-1; IBMIR: instant blood-mediated inflammatory reactions; PEG: polyethylene glycol; PGA: polyglycolic acid; PET: polyethylene terephthalate; bFGF: basic fibroblast growth factor; CR1: soluble complement receptor 1; PVA: polyvinyl alcohol hydrogel; VEGF: vascular endothelial growth factor; R3V6: three arginine and six valine; siRNA: short interfering RNA; iNOS: inducible nitric oxide synthase.