Effective formulation strategies for poorly water soluble drugs

Pathak, Kamla

doi:10.1016/b978-0-12-820043-8.00004-9

Cited by 6 publications

(3 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carbon dioxide and water are most commonly used supercritical solvents in this method. 127 The basis of this method is the dissolution of the drug and carrier materials (e.g., polymer) in the supercritical solvent at critical temperature and pressure and then its expansion by spraying in the expansion chamber at lower pressures, which leads to the deposition of materials and the formation of NPs. 128…”

Section: Supercritical Fluid-based Methodsmentioning

confidence: 99%

Current Advances in Nanotechnology-Mediated Delivery of Herbal and Plant-Derived Medicines

Jalili¹,

Bagherifar²,

Nokhodchi³

et al. 2023

Adv Pharm Bull

View full text Add to dashboard Cite

Phytomedicine has been used by humans since ancient times to treat a variety of diseases. However, the use of herbal medicines faces great challenges such as poor water and lipid solubility and instability, which lead to low bioavailability and insufficient therapeutic efficacy. Recently, it has been shown that nanotechnology-based drug delivery systems are appropriate to overcome the above-mentioned limitations. The present review first discusses herbal medicines and the challenges involved in formulation of these drugs. The different types of nano-based drug delivery systems used in herbal delivery and their potential to improve therapeutic efficacy are summarized and common techniques for preparing nanocarriers used in herbal drug delivery are also discussed. Finally, a list of nanophytomedicines that have entered clinical trials since 2010, as well as those that have been approved by the FDA, is presented.

show abstract

Section: Supercritical Fluid-based Methodsmentioning

confidence: 99%

Current Advances in Nanotechnology-Mediated Delivery of Herbal and Plant-Derived Medicines

Jalili¹,

Bagherifar²,

Nokhodchi³

et al. 2023

Adv Pharm Bull

View full text Add to dashboard Cite

show abstract

“…Therefore, they present problems such as insufficient bioavailability, the delayed onset of action and erratic absorption [6]. Strategies such as the preparation of solid dispersions, formation of cocrystals and salts, emulsions or confinement in mesoporous silica [7] solve some of the problems. The formulations of the APIs in the liquid state could also avoid the inconve-niences associated with their possible polymorphism.…”

Section: Introductionmentioning

confidence: 99%

Thymol+l-menthol eutectic mixtures: Thermophysical properties and possible applications as decontaminants

Bergua

Castro

Lafuente

et al. 2022

Journal of Molecular Liquids

View full text Add to dashboard Cite

“…There have been various effective approaches used to improve the solubility, dissolution, and bioavailability of these drugs [2][3][4][5][6][7][8]. Some of the most prevalent approaches are reduction in particle size (micronization, nanosizing) [9], cyclodextrin drug complexation [10,11], lipid based formation [12], using of surfactant [13,14], formation of a salt with alkalizing agent [15,16], and using different alkalizers in SD to change the pH of the microenvironment [17]. Among these, the incorporation of alkalizing agents in an SD has been identified as an effective method for increasing the dissolution rate of water-insoluble drugs [18].…”

Section: Introductionmentioning

confidence: 99%

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Ebraheem¹,

El-Gawad

Girgis

2022

J. Pharm. Res. Int.

View full text Add to dashboard Cite

The major objective of the current study is to implement a plan to enhance the dissolution rate and oral bioavailability of a poorly water-soluble aceclofenac. The drug is classified according to the biopharmaceutical classification system as class II drug. Amorphous alkalinized aceclofenac solid dispersion was formulated as a ternary mixture. This mixture was prepared by introducing polymeric carriers [polyvinylpyrrolidone, Hydroxy propyl beta cyclodextrin or Polyethylene glycol] and an alkalizer (Na2CO3) by applying the solvent evaporation method. Optimum formulations were compressed into tablets that were subjected to in-vitro studies compared to the market product Bristaflam and free drug containing one. Finally, tablets were assessed for stability studies and carrageenan-induced rat paw edema treatment to evaluate potentiated anti-inflammatory efficacy. Results showed that optimum amorphous alkalinized aceclofenac solid dispersion formulations containing polyvinylpyrrolidone K30 or Hydroxy propyl beta cyclodextrin in 1:5 ratio have significant in-vitro dissolution improvement (>90% in 10 min) compared to untreated aceclofenac. Solid-state characterization emphasized the conversion of the crystalline drug into the amorphous form with no drug−polymers interactions. Stability and dissolution studies ensured that tablets containing amorphous alkalinized solid dispersions were stable with strikingly improving dissolution behavior compared to Bristaflam or free drug containing tablets. Moreover, regarding anti-inflammatory activity against carrageenan induced paw edema, and histopathological examination, we concluded that amorphous alkalinized solid dispersions containing tablets are a promising approach to enhance the dissolution rate and oral bioavailability and hence anti-inflammatory efficacy of aceclofenac.

show abstract

Effective formulation strategies for poorly water soluble drugs

Cited by 6 publications

References 112 publications

Current Advances in Nanotechnology-Mediated Delivery of Herbal and Plant-Derived Medicines

Current Advances in Nanotechnology-Mediated Delivery of Herbal and Plant-Derived Medicines

Thymol+l-menthol eutectic mixtures: Thermophysical properties and possible applications as decontaminants

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Contact Info

Product

Resources

About