Effective Control of Moderate-Dose Cisplatin-induced Emesis by a Short-Course Regimen Including Metoclopramide, Chlorpromazine and Hydrocortisone: Results of a Randomized Trial with Metoclopramide Alone
Abstract:To improve the antiemetic effectiveness of a previously selected short regimen of moderate-dose metoclopramide (MCP), 80 patients were randomized to receive MCP either alone (regimen A) or in combination with low-dose chlorpromazine (CLP) and high-dose hydrocortisone (HDC) (regimen B) with the first course of cisplatin (50 mg/m2). The antiemetic effect was assessed over a 24-hour period only by objective means (duration and volume of vomiting in overnight fasting patients). The response was classifi… Show more
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