Effective combination therapy with high concentration of Minoxidil and Carboxygas in resistant Androgenetic alopecia: Report of nine cases

Abstract

Background Androgenetic alopecia (AGA) is widely characterized as the main reason of hair loss which most of the time it has been reported in adults regarding dermatological consultation. Also, it is broadly believed that the progressive miniaturization of hair follicles could be usually different at the age of onset. Aims Over the last decade, detecting and understanding newer genetic basis in AGA lead to provide better therapeutic approaches. We have highlighted on an evidence‐based method to treat AGA whose incidence is increasing significantly in our country. Patients/Methods In this study, 9 adults with AGA including 5 women and 4 men, age range of 25‐55 years, were treated with a combination of minoxidil (20%) by micro‐needling and carboxytherapy mediated by needling. All cases had a normal physical development. Hair numbers (density) and diameter were calculated using trichograms before and after treatment. Hair growth was assessed by the pull test as well. Results Our results showed that combination of high concentration of minoxidil and carboxygas extremely can increase the level of hair growth. Conclusion Our treatment effects on the terminal follicles using needling make sticky follicles become progressively smaller as a result of mechanical forces.

Clinical observation of basic fibroblast growth factor (bFGF) combined with minoxidil in the treatment of male androgenetic alopecia

“…The pharmacological effects of minoxidil include 1 (A) increasing blood circulation, because it can induce vasodilation and contribute to the overexpression of vascular endothelial growth factor; (B) accelerating the mitosis of hair matrix keratinocytes, promoting hair growth, and increasing hair diameter; (C) extending the growth period of hair follicles; (D) stimulating hair follicles to start a new growth cycle. Recent studies have revealed that 5% minoxidil is more effective than 2% minoxidil, which is used twice a day for 1 year (40% increase in reaction rate) 19 . In 2016, 5% minoxidil foam was approved for male androgenic alopecia (MAGA).…”

Micro needling: A novel therapeutic approach for androgenetic alopecia, A Review of Literature

“…Microneedling for AGA has been used either alone, 20 with saline solution, as a drug delivery system with minoxidil, [19][20][21][22][23][24] or with growth factors and PRP. [25][26][27][28] Other subsequent studies focused on the Platelet-rich plasma (PRP) combined with microneedling.…”

“…Microneedling for AGA has been used either alone, 20 with saline solution, as a drug delivery system with minoxidil, 19‐24 or with growth factors and PRP 25‐28 …”

“…The most recent study on minoxidil combined with microneedling is a case series by Nilforooshzadeh et al who added carboxytherapy mediated by needling in the treatment protocol 22 . In fact, 9 patients (men and women) with AGA received first of all carboxytherapy by needling (gage 27), and then 5% topical minoxidil (20%) by micro‐needling in the same area.…”

Autologous whole fat injection stimulates hair growth in resistant Androgenetic Alopecia: Report of nine cases

“…Recently, many techniques were used for the alopecia 3,4 . The most common methods for the androgenetic alopecia treatment are the topical minoxidil, the finasteride pills, and hair transplantation 5‐7 . Studies reported that traditional treatments are only a little effective in the androgenetic alopecia treatment 4 .…”