Effective Biodegradation of Aflatoxin B1 Using the Bacillus licheniformis (BL010) Strain

Wang, Ye; Zhang, Haiyang; Yan, Hai; Chen, Yin; Liu, Yang; Xu, Qianqian; Liu, Xiaolu; Zhang, Zhongbao

doi:10.3390/toxins10120497

Cited by 37 publications

(24 citation statements)

References 46 publications

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“…The aflatoxin reducing activity of the Bacillus strain B 285 from this study is in agreement with findings by previous researchers who reported activities up to 97.3%, depending on the bacterial strain as well as the conditions and duration of experiment [31][32][33]. Our findings are similar to those of Petchkongkaew et al [31]; who reported Bacillus lichenformis exhibiting 74% while B. subtilis had 85% reduction of AFB1 at 37 °C after 48 h of exposure, although the current exposure lasted 4 h only.…”

Section: Discussionsupporting

confidence: 93%

The in vitro Efficacy of Two Microbial Strains and Physicochemical Effects on their Aflatoxin Decontamination in Poultry Feeds

Tebetyo

Bogere

Nabulime

et al. 2020

Preprint

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Background: Contamination of animal feeds with aflatoxigenic fungi is a challenge to livestock farmers worldwide. Aflatoxins are very toxic fungal metabolites that are associated with carcinogenic, mutagenic, teratogenic, and estrogenic effects. The toxins affect animal productivity and may lead to deaths, causing enormous economic losses. Aflatoxin decontamination is a challenge to the feed industry, despite the several approaches available. This study investigated the efficacy of two microbial isolates, Bacillus spp (B285) and Yeast strain (Y833), in reducing Aflatoxin concentration in poultry feeds in comparison with a commonly used commercial chemical binder, Bentonite. The influence of the poultry feed matrix, pH, and temperature on the aflatoxin reducing activity by the two microorganisms was also explored. Results: The in vitro studies showed that the two microorganisms and the chemical binder reduced aflatoxins by over 74% of the original concentration. The chemical binder registered the highest reduction at 93.4%; followed by Y833 (83.6%), then the combination of Y833 and B285 (77.9%); and lastly B285 (74.9%). There was no significant (p>0.05) influence of temperature on the toxin reducing capacity of all the agents tested. The pHs 4.5 and 6.5 did not have a significant effect on the performance of both chemical binder and biological agents, however, the former performed better at pH 6.5 with 95% aflatoxin reduction compared to the microorganisms. The aflatoxin reducing activity was lower in presence of feeds compared to that in Phosphate Buffered Saline except for Y833 where no difference was observed. Conclusions: Although the feed components affected the aflatoxin reducing capacity of the test materials, the chemical binder was more effective than the microbial agents. Yeast strain was more effective than the bacterial strain in reducing the aflatoxin levels, however, both are promising strategies for countering the aflatoxin challenges in animal feeds. In response to the advocacy for use of biological control agents, there is need for more investigations to establish the safety of the microorganisms, the mechanism of decontamination and safety of the products; the optimum concentrations that can reduce aflatoxins in feeds to permissible levels and the effect of the toxin contamination levels on microbial efficiency.

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Section: Discussionsupporting

confidence: 93%

The in vitro Efficacy of Two Microbial Strains and Physicochemical Effects on their Aflatoxin Decontamination in Poultry Feeds

Tebetyo

Bogere

Nabulime

et al. 2020

Preprint

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“…Toxin binding can reach saturation rapidly and is reversible, and mycotoxins are not modified chemically during the process (Bueno et al, 2007). It must be noted that some yeasts (reviewed by Pfliegler et al, 2015) and bacteria (Wang Y. et al, 2018) are known to be able to enzymatically degrade mycotoxins if applied in viable form.…”

Section: Microbial Biocontrol and Microbial Detoxification Products Fmentioning

confidence: 99%

Adverse Effects, Transformation and Channeling of Aflatoxins Into Food Raw Materials in Livestock

et al. 2019

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“…Pseudomonas spp. Stenotrophomonas spp., Arthrobacter spp., and members of the family Flavobacteriaceae were shown in vitro to produce aflatoxin-degrading enzymes causing a significant reduction (>90%) in the levels of AFB1, AFM1 and/or AFB2 [217][218][219][220]. However, for these microorganisms to be effective in vivo, they have to colonize the intestinal tract and express sufficient levels of the aflatoxin-degrading enzymes.…”

Section: Reducing the Risk By Interfering With The Bioavailability Ofmentioning

confidence: 99%

Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint

Benkerroum¹

2019

Preprint

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Among the array of structurally and toxicologically diverse mycotoxins, aflatoxins have attracted the most interest of scientific research due to their high toxicity and incidence in foods and feeds. Despite the undeniable progress made in various aspects related to aflatoxins, the ultimate goal consisting of reducing the associated public health risks worldwide is far from being reached due to multiplicity of social, political, economic, geographic, climatic, and development factors. However, a reasonable degree of health protection is attained in industrialized countries owing to their scientific, administrative, and financial capacities allowing them to use high-tech agricultural management systems. Less fortunate situation exists in equatorial and sub-equatorial developing countries mainly practicing traditional agriculture managed by smallholders for subsistence, and where the climate is suitable for mould growth and aflatoxin production. Accordingly, it is difficult to harmonize the regulatory standards of aflatoxins worldwide, which prevents agri-foods of developing countries from access to the market of industrialized countries. To tackle the multi-facetted aflatoxin problems, actions should be taken collectively by the international community involving scientific research, technological and social development, environment protection, etc. International cooperation should foster technology transfer and exchange of pertinent technical information. This review presents the main historical discoveries leading to our present knowledge on aflatoxins and the challenges that should be addressed presently and in the future at various levels to ensure higher health protection for everybody. In short, it aims to elucidate where we come from and where we should go in terms of aflatoxin research/development.

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Effective Biodegradation of Aflatoxin B1 Using the Bacillus licheniformis (BL010) Strain

Cited by 37 publications

References 46 publications

The in vitro Efficacy of Two Microbial Strains and Physicochemical Effects on their Aflatoxin Decontamination in Poultry Feeds

The in vitro Efficacy of Two Microbial Strains and Physicochemical Effects on their Aflatoxin Decontamination in Poultry Feeds

Adverse Effects, Transformation and Channeling of Aflatoxins Into Food Raw Materials in Livestock

Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint

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