Effective apparent diffusion coefficient parameters for differentiation between mass-forming autoimmune pancreatitis and pancreatic ductal adenocarcinoma

Ren, Hainan; Mori, Nobuhiro; Hamada, Shin; Takasawa, Chiaki; Mugikura, Shunji; Masamune, Atsushi; Takase, Kei

doi:10.1007/s00261-020-02795-x

Cited by 11 publications

(2 citation statements)

References 31 publications

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“…PDAC with reduced diffusion of water molecules typically shows a high SI on DWI. [ 27 , 28 ] However, one study reported that PDACs could not be detected as a mass with a SI higher than that of a normal pancreas because PDACs are occasionally accompanied by a variable degree of obstructive pancreatitis showing high SI on DWI. [ 29 ] Furthermore, the low spatial resolution of DWI might be another drawback.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group

Ren

Mori

Hirasawa

et al. 2021

JCIS

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Objectives: The objectives of the study was to evaluate the diagnostic performance of findings on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and magnetic resonance cholangiopancreatography (MRCP) separately and to identify an optimal Boolean interpretation model for discriminating patients with small pancreatic ductal adenocarcinoma (PDAC) from control groups in clinical practice. Material and Methods: We retrospectively enrolled 30 patients with surgery confirmed small PDAC (≤20 mm) and 302 patients without pancreatic abnormality between April 2008 and February 2020. The presence of masses was evaluated by T1WI, T2WI, and DWI. Abnormality of the main pancreatic duct (MPD) was evaluated by T2WI and MRCP. Multivariate logistic regression analysis was performed to select significant sequences for discriminating the small PDAC and control groups. Boolean operators “OR” or “AND” were used to construct sequence combinations. Diagnostic performances of these sequences and combinations were evaluated by X2 tests. Results: The sensitivity of T2WI was lowest (20%) for detecting masses. For evaluating MPD abnormality, sensitivity was higher for MRCP than for T2WI (86.7% vs. 53.3%). Multivariate logistic regression analysis showed that T1WI and DWI for detecting the presence of masses and MRCP for evaluating MPD abnormality were significantly associated with differentiation between the two groups (P = 0.0002, P = 0.0484, and P < 0.0001, respectively). Seven combinations were constructed with T1WI, DWI, and MRCP. The combination of findings on “T1WI or DWI or MRCP” achieved the highest sensitivity of 96.7% and negative predictive value of 99.6%. Conclusion: The combination of findings on “T1WI or DWI or MRCP” might be an optimal interpretation model for discriminating small PDAC from control groups in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group

Ren

Mori

Hirasawa

et al. 2021

JCIS

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“…7 a). Ren et al reported that the apparent diffusion coefficient (ADC) map helped distinguish mass-forming-type AIP from PDAC [ 27 ]. They found that the areas under the curve (AUCs) of receiver operating characteristic (ROC) were maximized when using the maximum ADC value as a parameter.…”

Section: Recent Researchmentioning

confidence: 99%

Imaging diagnosis of autoimmune pancreatitis: computed tomography and magnetic resonance imaging

2021

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Autoimmune pancreatitis (AIP) is a pancreatic phenotype of IgG4-related systemic disease. Since its first description in the literature, characteristic imaging features have gradually become known to many clinicians encompassing various specialties in the past quarter century. CT and MRI have been the workhorses for imaging diagnosis of AIP. Typical features include sausage-like swelling of the focal or entire pancreas, duct-penetrating sign, a capsule-like rim of the affected lesions, and homogeneous delayed enhancement or enhanced duct sign after contrast administration, as well as characteristic combined findings reflecting coexisting pathologies in the other organs as a systemic disease. In this review, recent and future developments in CT and MRI that may help diagnose AIP are discussed, including restricted diffusion and perfusion and increased elasticity measured using MR.

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Letter to the editor on “High signal intensity on diffusion‐weighted magnetic resonance images is a useful finding for detecting early‐stage pancreatic cancer”

et al. 2021

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Effective apparent diffusion coefficient parameters for differentiation between mass-forming autoimmune pancreatitis and pancreatic ductal adenocarcinoma

Cited by 11 publications

References 31 publications

Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group

Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group

Imaging diagnosis of autoimmune pancreatitis: computed tomography and magnetic resonance imaging

Letter to the editor on “High signal intensity on diffusion‐weighted magnetic resonance images is a useful finding for detecting early‐stage pancreatic cancer”

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