Effective accumulation of poly(vinylpyrrolidone‐<i>co</i>‐vinyl laurate) into the spleen

Yoshioka, Yasuo; Tsutsumi, Yasuo; Mukai, Yohei; Shibata, Hiroko; Okamoto, Takayuki; Kaneda, Yoshihisa; Tsunoda, Shin‐ichi; Kamada, Haruhiko; Koizumi, Keiichi; Yamamoto, Yoko; Mu, Yu; Kodaira, Hiroshi; Sato-Kamada, Keiko; Nakagawa, Shinsaku; Mayumi, Tadanori

doi:10.1002/jbm.a.30059

Cited by 12 publications

(4 citation statements)

References 15 publications

(22 reference statements)

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“…Effective accumulation of PVP-co-vinyl laurate in the spleen, and of the PVP-co-styrene in the liver, was reported by Tsutsumi and coworkers. [58] Mannan-mediated gene delivery for cancer immunotherapy was discussed by Aposolopoulos and coworkers. [59] Actively targeted liposomes…”

Section: Dox Sp1049cmentioning

confidence: 99%

Polymers for targeted and/or sustained drug delivery

Jagur‐Grodzinski¹

2008

Polymers for Advanced Techs

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Recent advances in the use of polymers for passive targeting of drugs attached or incorporated into polymeric species (enhanced permeability and retention, EPR) as well as active targeting of drugs by ligands or antibodies of receptors overexpressed on the surface of the targeted cells, is discussed in the present review. Examples of sustained, slow release of a drug incorporated into a polymeric matrix are cited. Drugs used for passive modes of targeting have been described in the context of polymer‐drug conjugates, drugs in the polymer coated liposomes, and drugs inserted into polymeric micelles. Active targeting of the drugs and their internalization by receptors, on the surface of the targeted cells, was also discussed. Release of the drugs inside cells, after are broken the environmentally sensitive links attaching them to polymeric platforms was described. Examples illustrate targeting drug by local heat generated by ultrasound, or by photodynamic treatment. Delivery modes of drugs incorporated into other nanoparticles and the concept of prodrugs have been investigated. Copyright © 2008 John Wiley & Sons, Ltd.

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Section: Dox Sp1049cmentioning

confidence: 99%

Polymers for targeted and/or sustained drug delivery

Jagur‐Grodzinski¹

2008

Polymers for Advanced Techs

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“…In literature, there are some examples for the application of poly(vinyl esters) in the field of medical polymers. Yoshioka et al use thermally polymerized vinyl laurate copolymers with N ‐vinyl pyrrolidone as drug delivery agents18 and Miura et al describe the thermal polymerization of enzymatic glucoconjugates with vinyl esters as possible polymers for biomaterials 19…”

Section: Introductionmentioning

confidence: 99%

Vinyl esters: Low cytotoxicity monomers for the fabrication of biocompatible 3D scaffolds by lithography based additive manufacturing

Heller

Schwentenwein

Russmueller

et al. 2009

J. Polym. Sci. A Polym. Chem.

138

142

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Lithography based additive manufacturing technologies (AMT) like stereolithography or digital light processing have become appealing methods for the fabrication of 3D cellular scaffolds for tissue engineering and regenerative medicine. To circumvent the use of (meth)acrylate-based photopolymers, that suffer from skin irritation and sometimes cytotoxicity, new monomers based on vinyl esters were prepared. In vitro cytotoxicity studies with osteoblast-like cells proofed that monomers based on vinyl esters are significantly less cytotoxic than (meth)acrylates. Photoreactivity was followed by photo-differential scanning calorimetry and the mechanical properties of the photocured materials were screened by nanoindentation. Conversion rates and indentation moduli between those of acrylate and methacrylate references could be observed. Furthermore, osteoblast-like cells were successfully seeded onto polymer specimens. Finally, we were able to print a 3D test structure out of a vinyl ester-based formulation by l-SLA with a layer thickness of 50 lm. For in vivo testing of vinyl esters these 3D scaffolds were implanted into surgical defects of the distal femoral bone of adult New Zealand white rabbits. The obtained histological results approved the excellent biocompatibility of vinyl esters. V V C 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 6941-6954, 2009

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“…Previously, we showed that the therapeutic antitumor effects were stronger when tumor necrosis factor-a was conjugated with polyvinylpyrrolidone (PVP) than with PEG; this is because PVP is better than PEG for prolonging plasma half-life and increasing stability in blood. 20,21) Therefore, conjugation of PVP to Adv could produce a more potent antitumor therapeutic agent. We are now investigating the usefulness of PVP-Ad for cancer gene therapy.…”

Section: Resultsmentioning

confidence: 99%

Adenovirus Vector Covalently Conjugated to Polyethylene Glycol with a Cancer-Specific Promoter Suppresses the Tumor Growth through Systemic Administration

Yao

Yoshioka

Morishige

et al. 2010

Biological & Pharmaceutical Bulletin

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Gene therapy is expected to play a key role in next-generation cancer therapy together with the conventional modalities for the treatment of cancer, such as surgery, chemotherapy, and radiotherapy. 1) Use of adenovirus vectors (Adv) in gene therapy has been developed in diverse animal models and clinical trials because Adv can be propagated to high yields and has the capacity to efficiently transduce a wide variety of cell types and tissues regardless of the mitotic status of the cell. 2,3) In several clinical trials, intratumoral injection of Adv has demonstrated therapeutic efficacy against primary tumors. 4,5) However, successful cancer gene therapy also requires treatment of unresectable primary cancers and distant metastases, which are the major cause of cancer mortality. To treat unresectable primary and metastatic cancers, Adv must be administered systemically, but its effects must be restricted to tumor cells. The major disadvantage in treating cancer with systemically administered conventional Adv is related to its accumulation in the liver immediately after systemic injection, which can cause severe liver toxicity. 6)Therefore, to enable the application of Adv to the treatment of both primary and metastatic cancers, it is necessary to develop Adv with the capacity for tumor-selective distribution and gene expression after systemic administration.In a previous study, we generated a dual cancer-specific targeting vector system by using Adv covalently conjugated to polyethylene glycol (PEG), for transductional targeting, and a cancer-specific promoter, for transcriptional targeting. 7)Covalent conjugation to PEG (PEGylation) can prolong the plasma half-life of Adv, prevent hepatic uptake, and alter the tissue distribution of Adv because of the steric hindrance of the PEG. 3,7,8) We showed that systemic administration of PEGylated Adv (PEG-Ad) with 20-kDa PEG at a 45% modification ratio resulted in higher tumor-selective transgene expression than unmodified Adv.7) In addition, we showed that the telomere reverse transcriptase (TERT) promoter-driven PEG-Ad (PEG-Ad-TERT), which contained the herpes simplex virus thymidine kinase (HSVtk) gene as the therapeutic gene, induced strong antitumor effects against metastasis without any side effects. By comparison, a conventional cytomegalovirus (CMV) promoter-driven PEG-Ad produced strong antitumor effects but induced unwanted side effects. 7)Therefore, PEG-Ad-TERT can be regarded as a prototype Adv with suitable efficacy and safety for systemic cancer gene therapy against metastasis, although PEG-Ad-CMV might not be suitable. However, it is not clear whether PEGAd-TERT can be used for the treatment of unresectable primary cancers.In this study, we examined the therapeutic effects of systemically administered PEG-Ad-TERT for the treatment of primary tumors. MATERIALS AND METHODS Mice and Cell LinesFemale 5-week-old C57BL6 mice were purchased from SLC Inc. (Hamamatsu, Japan). All procedures involving animal experimentation were performed in ; 7-6-8 Saito-Asagi, Ib...

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Effective accumulation of poly(vinylpyrrolidone‐co‐vinyl laurate) into the spleen

Cited by 12 publications

References 15 publications

Polymers for targeted and/or sustained drug delivery

Polymers for targeted and/or sustained drug delivery

Vinyl esters: Low cytotoxicity monomers for the fabrication of biocompatible 3D scaffolds by lithography based additive manufacturing

Adenovirus Vector Covalently Conjugated to Polyethylene Glycol with a Cancer-Specific Promoter Suppresses the Tumor Growth through Systemic Administration

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