Effection of Lactic Acid Dissociation on Swelling-Based Short-Chain Fatty Acid Vesicles Nano-Delivery

Chen, Lichun; Zhao, Huimin; Xue, Songwen; Chen, Kexian; Zhang, Yue

doi:10.3390/foods11111630

Cited by 3 publications

(2 citation statements)

References 46 publications

(52 reference statements)

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“…The variation in the pH of PWM was strongly correlated with the lactic acid metabolism capacity of the dominant bacterial genera ( Figure 3 B). Lactobacillus produces large quantities of lactic acid, which has a lower dissociation constant and higher acid effect than enolic acids, such as acetic and butyric acids; therefore, an increase in lactic acid content results in a reduced pH [ 26 ]. NH 4 + -N serves as a nitrogen source for microbial growth and affects the community composition and metabolic function of the bacteria present in PM [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Bacterial Communities Found in Pit-Wall Mud and Factors Driving Their Evolution

Zhou

et al. 2023

Foods

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Pit-wall mud (PWM) fosters bacterial communities involved in Baijiu production. PWM varies depending on pit age and height. In this study, we explored the bacterial communities in PWM and factors driving their evolution. The abundance and diversity of bacterial communities were low in new PWM (NPWM). In old PWM (OPWM), similar but diverse bacterial communities were observed at different heights. Lactobacillus was the predominant genus in NPWM, and Caproiciproducens, Aminobacterium, Hydrogenispora, Lactobacillus, Petrimonas, Syntrophomonas, and Sedimentibacter were the dominant genera in OPWM. A decrease was noted in the abundance of Lactobacillus, which indicated evolution. Among all the physicochemical properties, pH had the highest degree of interpretation with an R2 value of 0.965. pH also exerted the strongest effect on bacterial communities. The path coefficients of pH on bacterial community diversity and abundance were 0.886 and 0.810, respectively. Caproiciproducens and Clostridium sensu stricto 12 metabolized lactic acid, inhibiting the growth of Lactobacillus at a suitable pH, which led to the maturation of PWM. Our findings enrich the literature on the evolution of bacterial communities in PM and the maturation of PM.

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Section: Discussionmentioning

confidence: 99%

Bacterial Communities Found in Pit-Wall Mud and Factors Driving Their Evolution

Zhou

et al. 2023

Foods

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“…2F). We speculated that this different release behavior may be related to the stability of vesicles in different environments [35,36]. Therefore, the vesicle size was measured before and after 12 hours of immersion in PBS with 100 µM H 2 O 2 , respectively.…”

Section: Release Behavior and Biocompatibility Of Vesiclesmentioning

confidence: 99%

ROS-Responsive Sequential Release Systems with Excellent Biofilm Permeability for Enhanced Antibacterial and Regeneration-promoting Therapy in Periodontitis

Zeng

Shen

et al. 2023

Preprint

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Periodontitis is the sixth most common chronic inflammatory disease caused by plaque biofilms and closely related to many systemic diseases. In particular, the problems of deep lesion location and sequential treatment of antibacterial and pro-regenerative abilities need to be addressed. We created a novel ROS responsive system (CHX@PCL-PLG) for efficient therapy of refractory periodontitis based on a “three-birds-with-one-stone” strategy, which integrates the biofilm penetration, nitric oxide (NO) sterilization, and NO-mediated pro-angiogenic property into one system. The above system was fabricated by self-assembling vesicles formed by amphiphilic polymers containing poly-ε-caprolactone and guanidinated-poly-ε-lysine as carriers (PCL-PLG) loaded with chlorhexidine (CHX). CHX@PCL-PLG can efficiently penetrate into biofilm under the action of abundant guanidine groups on the vesicle’s surface. Subsequently, the guanidine groups of vesicles respond to the high level of ROS within the biofilm by releasing NO and CHX in a targeted manner to play a synergistic antibacterial and biofilm scavenging function. More importantly, following effective elimination all bacteria from the periodontal pockets, the residual guanidine groups could further produce trace amounts of NO, which promoted angiogenesis and epithelialization of the wound tissue to significantly facilitating wound healing. In conclusion, this study demonstrates that CHX@PCL-PLG makes full use of the characteristics of guanidine groups to significantly disrupt biofilms and promote tissue regeneration for the effective treatment of periodontitis as well as various biofilm-related diseases.

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