Effect-Targeted Mapping of Potential Estrogenic Agonists and Antagonists in Wastewater via a Conformation-Specific Reporter-Mediated Biosensor
Jisui Tan,
Fangxu Li,
Lanhua Liu
et al.
Abstract:Wastewater treatment plants (WWTPs) are regarded as the
main sources
of estrogens that reach the aquatic environment. Hence, continuous
monitoring of potential estrogenic-active compounds by a biosensor
is an appealing approach. However, existing biosensors cannot simultaneously
distinguish and quantify estrogenic agonists and antagonists. To overcome
the challenge, we developed an estrogen receptor-based biosensor that
selectively screened estrogenic agonists and antagonists by introducing
rationally designed… Show more
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