Effect size varies based on calculation method and may affect interpretation of treatment effect: an illustration using randomised clinical trials in osteoarthritis
Thomas J. Schnitzer,
Philip G. Conaghan,
Francis Berenbaum
et al.
Abstract:Background
To illustrate how (standardised) effect sizes (ES) vary based on calculation method and to provide considerations for improved reporting.
Methods
Data from three trials of tanezumab in subjects with osteoarthritis were analyzed. ES of tanezumab versus comparator for WOMAC Pain (outcome) was defined as least squares difference between means (mixed model for repeated measures analysis) divided by a pooled standard deviation (SD) of outcome… Show more
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