Effect on the quality of blood components after simulated blood transfusions using volumetric infusion pumps

Abstract

There was no adverse effect on the in vitro quality of RBCs or PCs after simulated transfusion using volumetric infusion pumps. A decrease in PLT activation was observed, which can probably be explained by capturing of activated or damaged PLTs in the 200-µm filter present in the infusion system.

Quantitative assessment of haemolysis secondary to modern infusion pumps

“…We believe that the use of this ASV could at least partially explain why we observed more haemolysis with the Infusomat ® Space pump than was reported by Lieshout‐Krikke et al . .…”

“…For Colleague ® CXE, no published data exist at transfusion rates higher than 20 ml/h. For Infusomat ® Space, the previously reported data are questionable, as explained before .…”

An Open-Labelled, Randomized Cross-Over Study of the Effect of Electromechanical Pumps versus Conventional Gravity Flow on Platelet Transfusion in Adult Haematology Patients

“…The necessity for an accurate and rapid transfusion rate in some medical situations, particularly in the paediatric setting, dictates the need for highly efficient infusion pump devices. Although the electromechanical infusion pumps were designed originally for delivery of crystalloid solutions, and despite the fact that randomized trials exploring their possible effect(s) on viable blood cells are lacking, nowadays they are routinely used for different blood product transfusions [4,8,9]. There are no robust data in the literature on the effect of infusion pumps on different blood products; in addition, newer devices are constantly being developed and are entering the medical market.…”

“…There are no robust data in the literature on the effect of infusion pumps on different blood products; in addition, newer devices are constantly being developed and are entering the medical market. For most of these infusion pumps, it is not clear whether the use of these devices is associated with detrimental effects on platelets [8]. Therefore, our randomized trial also documents the effects of the different currently available infusion pumps on the platelets.…”

“…Medical staff recognize that the alarm systems associated with electromechanical infusion pumps provide quality of care in a timely fashion compared to the gravity infusion method. In addition, the alarm system decreases the number of times a member of the medical staff is required to monitor the infusion rate [8,9]. In theory, platelets may be mechanically damaged or functionally altered, i.e.…”