Effect on Reproductive System of Carbon Nanomaterials

Liu, Ying; Chen, Chunying

doi:10.1002/9783527692866.ch11

Cited by 3 publications

(2 citation statements)

References 92 publications

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“…These compounds are widely used in the pharmaceutical industry and as drug carriers. Acute or chronic exposure to CNTs has been associated with disorders in the brain (10), heart (11), liver (11), intestine (12), lung (13), gills (14), kidney (15), spleen (16), central nervous system (17), immune system (18), reproductive organs, and neuroendocrine system (9,19). Although the consumption of CNTs in healthrelated aspects is still to be evaluated quantitatively, as the exposure risk of employees and consumers increases, qualitative assessment of the designed stable suspensions containing various forms of CNTs, is essential for safe usage in medicine.…”

Section: Introductionmentioning

confidence: 99%

Spermatotoxic Effects of Single-Walled and Multi-Walled Carbon Nanotubes on Male Mice

et al. 2020

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Carbon-based nanomaterials possess a remarkably high potential for biomedical applications due to their physical properties; however, their detrimental effects on reproduction are also concerned. Several reports indicate the toxicity of carbon nanotubes (CNT); nevertheless, their impact on intracellular organelles in the male reproductive organs has not been fully elucidated. Herein, we report on the reprotoxicity of single-walled (SWCNT) and multi-walled carbon nanotubes (MWCN) on several intracellular events and histological criteria in pubertal male BALB/c mice orally treated with 0, 10, and 50 mg/kg/day doses for 5 weeks. Biomarkers of oxidative stress and mitochondrial functionality, histopathological alterations, and epididymal sperm characteristics were determined. Oral administration of CNTs at 10 and 50 mg/kg evoked a significant decrement in weight coefficient, sperm viability and motility, hypo-osmotic swelling (HOS) test, sperm count, mitochondrial dehydrogenase activity, ATP content, total antioxidant capacity, and GSH/GSSH ratio in the testis and epididymal spermatozoa. On the other hand, percent abnormal sperm, testicular and sperm TBARS contents, protein carbonylation, ROS formation, oxidized glutathione level, and sperm mitochondrial depolarization were considerably increased. Significant histopathological and stereological alterations in the testis occurred in the groups challenged with CNTs. The current findings indicated that oxidative stress and mitochondrial impairment might substantially impact CNTs-induced reproductive system injury and sperm toxicity. The results can also be used to establish environmental standards for CNT consumption by mammals, produce new chemicals for controlling the rodent populations, and develop therapeutic approaches against CNTs-associated reproductive anomalies in the males exposed daily to these nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Spermatotoxic Effects of Single-Walled and Multi-Walled Carbon Nanotubes on Male Mice

et al. 2020

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“…Infection detection, targeted treatment, microbicides and vaccine design for prevention, are all applications of Carbon nanostructures in the field of reproductive infections. These nanostructures can be used as alternative for surgical intervention in ectopic pregnancy, trophoblastic diseases, endometriosis and uterine fibroids ( Azizi-Lalabadi et al ., 2020 ; Bernabò et al ., 2019 ; 2020 ; George et al ., 2018 ; He et al ., 2013 ; Kang et al ., 2007 ; Krishnaraj et al ., 2014 ; Liu et al, 2017 ; Liu & Chen, 2016 ; Maleki Dizaj et al ., 2015 ; Ramal-Sanchez et al ., 2019 ; Saliev, 2019 ; Zare-Zardini et al ., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Advantages and disadvantages of using Carbon Nanostructures in Reproductive Medicine: two sides of the same coin

Zare‐Zardini

Hatamizadeh

Haddadzadegan

et al. 2022

JBRA Assisted Reproduction

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Carbon nanostructures are important nanomaterial with interesting physical and chemical properties. These nanostructures have been assessed for application in different fields of medicine, such as cancer detection and treatment, Parkinson disease, reproductive medicine, etc. This nanomaterial can be used in reproductive medicine as a drug delivery system, antifungal, antiviral, and antibacterial agent, condom-coating agent, enhancer of sperm fertilizing ability, ectopic pregnancy treatment, trophoblastic diseases, endometriosis, uterine fibroids, and Assisted Reproduction Techniques (ART) improvement. The other side of this coin involves various side effects of carbon nanostructures, especially negative effects on reproductive systems. All carbon nanostructures showed toxicity on the reproductive system by producing reactive oxygen species and oxidative stress. Less attention has been given to the unique properties of carbon nanostructures, except for their practical attractiveness, the other side of this coin, namely the risks and side effects of these compounds - especially in the case of a reproductive system that supports the survival and health of future generations. Therefore, we suggest paying particular attention to the negative aspects of the increasing use of carbon nanostructures.

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Advances in Nanopharmacology: Focus on Reproduction, Endocrinology, Developmental Alterations, and Next Generational Effects

Ommati

Retana‐Márquez

Najibi

et al. 2023

Nanopharmacology and Nanotoxicology: Clinical Implications and Methods

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To date, the application of a wide range of nanostructured materials (NSMs), such as carbon nanotubes, silica compounds, metallic nanoparticles, nanovesicles (liposomes and exosomes), nanohydrogels (NHGs), nanohydroxyapatite (NHAPs), chitosans, and graphenes, has gained interest for various applications in biomedical sciences. These nanoparticles presented outstanding biological and mechanical features. Although the biocompatibility of NSMs is highly investigated, their interaction with the reproductive system is less exploited. On the other hand, recently, NSMs-mediated drug delivery presents a competent method in reproduction biology. Emerging evidence from the literature supports the considerable progress in nanopharmacology, which has transformed the theory of targeted biological delivery, permitting the engineering of complex biocompatible organic/inorganic platforms with a vast loading capacity, highly selective affinity, stability, and capacity for multiple, simultaneous usages; all within the nanometer scale. In this chapter, first, the potential application of NSMs in the field of reproduction is highlighted. Then, the possible effects of these materials on reproduction, endocrinology, developmental alterations, and next-generation impact will be discussed. The data presented in this chapter could provide insight into the effect of NSMs on the reproductive system and development and lead to better risk assessment of these materials or synthesis of safe nano-drug delivery systems to the reproductive organs.

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Effect on Reproductive System of Carbon Nanomaterials

Cited by 3 publications

References 92 publications

Spermatotoxic Effects of Single-Walled and Multi-Walled Carbon Nanotubes on Male Mice

Spermatotoxic Effects of Single-Walled and Multi-Walled Carbon Nanotubes on Male Mice

Advantages and disadvantages of using Carbon Nanostructures in Reproductive Medicine: two sides of the same coin

Advances in Nanopharmacology: Focus on Reproduction, Endocrinology, Developmental Alterations, and Next Generational Effects

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