Effect on haemostasis of intravenous injection of α2-antiplasmin in cats treated with streptokinase

Streptokinase - Biochemistry and Clinical Application

“…Similarly the SK-plasmin complex was shown to react very slowly with a2-macroglobulin in a tem perature-sensitive reaction while plasmin had no such dependence [24], complex, the SK is degraded to a 26,000-dalton form with loss in activator activity [16]. We had also found that this complex is inactivated by a2-antiplasmin and ci2-macroglobulin which explains why streptokinase infusion in the dog does not result in exten sive degradation of fibrinogen in the circula tion [25], In cats, streptokinase infusion re sults in depletion of plasminogen and fibrin ogen in the circulation similar to changes seen in human [26]. Although purified rabbit plasminogen requires a large excess of strep tokinase for activation, significant thrombo lysis is achieved in vivo with low doses of streptokinase due to enhancement of activa tion by rabbit fibrin [27],…”