Effect on cell surface hydrophobicity and susceptibility of<i>Helicobacter pylori</i>to medicinal plant extracts

Annuk, Heidi; Hirmo, Siiri; Türi, E.; Mikelsaar, Marika; Arak, Elmar; Wadström, Torkel

doi:10.1111/j.1574-6968.1999.tb13447.x

Cited by 75 publications

(14 citation statements)

References 11 publications

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“…For example, the aqueous extract of bearberry has been shown to alter the hydrophobicity of E . coli (Turi et al 1999) and Helicobacter pylori (Anuuk et al 1999). In another study, Nostro et al (2004) found that surface hydrophobicity and adherence of Streptococcus mutans was reduced when bacteria were grown in the presence of the Helichrysum italicum extract.…”

Section: Discussionmentioning

confidence: 99%

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

2012

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Adhesion of bacteria to epithelial tissue is an essential step in the progression of the urinary tract infections. Reduction of virulence factors responsible for microbial attachment may help to decrease or inhibit colonization of the host organism by pathogens. In the age of increasing bacterial antibiotic resistance, more and more attention is being paid to the use of plants and/or their bioactive components in the prevention and treatment of human infections. Asiatic acid (AA) and ursolic acid (UA), two plant secondary metabolites, were used as potential antibacterial agents. The current study aimed to determine the possible impact of AA and UA on morphology, hydrophobicity, and adhesion of clinical uropathogenic Escherichia coli strains (UPEC) to the uroepithelial cells. Our work describes for the first time the effects exerted by AA and UA on virulence factors of UPECs. The impact of both acids on the cell surface hydrophobicity of the investigated strains was very weak. The results clearly show the influence of AA and UA on the presence of P fimbriae and curli fibers, morphology of the UPECs cells and their adhesion to epithelium; however, some differences between activities of AA and UA were found.

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Section: Discussionmentioning

confidence: 99%

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

2012

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“…(1999) investigated the effect of the leaves (aqueous extract) of Arctostaphylos uva-ursi (Ericaceae) and Vaccinium vitis-idaea (Ericaceae), for susceptibility of ten strains of Helicobacter pylori . It was established that the extracts were clearly bacteriostatic [75]. …”

Section: Plants With Peptic Anti-ulcer Activitymentioning

confidence: 99%

Tannins, Peptic Ulcers and Related Mechanisms

Jesus

Falcão

Gomes

et al. 2012

IJMS

133

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This review of the current literature aims to study correlations between the chemical structure and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins with which they come into contact. In gastric ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Moreover, in several experimental models of gastric ulcer, tannins have been shown to present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and they are involved in gastrointestinal tract antiinflammatory processes. The presence of tannins explains the anti-ulcer effects of many natural products.

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“…Its antagonistic properties against enteral pathogens ( Salmonella Typhimurium and Shigella sonnei ), and urinary tract infections caused by E. coli , were assessed by a streak line procedure on plates containing modified (pH 7.2) MRS medium (135–137). In different environmental conditions (microaerobic and anaerobic milieus) the production of lactic acid by strain ME-3 correlated well with its antagonistic activity.…”

Section: Elaboration Of Probiotic Lfermentum Me-3 At the University mentioning

confidence: 99%

Lactobacillus fermentumME-3 – an antimicrobial and antioxidative probiotic

Mikelsaar

Zilmer

2009

Microbial Ecology in Health and Disease

Self Cite

178

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The paper lays out the short scientific history and characteristics of the new probiotic Lactobacillus fermentum strain ME-3 DSM-14241, elaborated according to the regulations of WHO/FAO (2002). L. fermentum ME-3 is a unique strain of Lactobacillus species, having at the same time the antimicrobial and physiologically effective antioxidative properties and expressing health-promoting characteristics if consumed. Tartu University has patented this strain in Estonia (priority June 2001, patent in 2006), Russia (patent in 2006) and the USA (patent in 2007). The paper describes the process of the identification and molecular typing of this probiotic strain of human origin, its deposition in an international culture collection, and its safety assessment by laboratory tests and testing on experimental animals and volunteers. It has been established that L. fermentum strain ME-3 has double functional properties: antimicrobial activity against intestinal pathogens and high total antioxidative activity (TAA) and total antioxidative status (TAS) of intact cells and lysates, and it is characterized by a complete glutathione system: synthesis, uptake and redox turnover. The functional efficacy of the antimicrobial and antioxidative probiotic has been proven by the eradication of salmonellas and the reduction of liver and spleen granulomas in Salmonella Typhimurium-infected mice treated with the combination of ofloxacin and L. fermentum strain ME-3. Using capsules or foodstuffs enriched with L. fermentum ME-3, different clinical study designs (including double-blind, placebo-controlled, crossover studies) and different subjects (healthy volunteers, allergic patients and those recovering from a stroke), it has been shown that this probiotic increased the antioxidative activity of sera and improved the composition of the low-density lipid particles (LDL) and post-prandial lipids as well as oxidative stress status, thus demonstrating a remarkable anti-atherogenic effect. The elaboration of the probiotic L. fermentum strain ME-3 has drawn on wide international cooperative research and has taken more than 12 years altogether. The new ME-3 probiotic-containing products have been successfully marketed and sold in Baltic countries and Finland.

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Effect on cell surface hydrophobicity and susceptibility ofHelicobacter pylorito medicinal plant extracts

Cited by 75 publications

References 11 publications

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

Tannins, Peptic Ulcers and Related Mechanisms

Lactobacillus fermentumME-3 – an antimicrobial and antioxidative probiotic

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