Effect on cell growth, viability and migration of geraniol and geraniol-containing essential oil from Lippia alba (Verbenaceae) on gastric carcinoma cells

Geraniol ve vitamin C’nin dietilnitrozamin kaynaklı deneysel hepatoselüler karsinogenez üzerindeki etkisi

“…Today, studies in cell culture have a vital place in research activities 10,13,17,19,21,22,[25][26][27][28][29] . With the acceleration of cancer research, the use of cancer cell lines has gained great importance, especially in the development of cancer drugs and in determining their effects 22 .…”

“…Ortiz et al demonstrated that geraniol had an antiproliferative effect against the growth of cancer cells 13 . Also in the literature, detected in vivo and in vitro cells that it caused changes in cell permeability, membrane, and ion channel perturbation 17,20 .…”

“…It is found as the main ingredient of rose and palmarosa oil while lemon ginger, rose, orange, etc. It is present in plants as an active ingredient 12,13 . Geraniol has a characteristic rose scent and a sweet, waxy, citrus-like flavor like a rose.…”

“…Geraniol has a characteristic rose scent and a sweet, waxy, citrus-like flavor like a rose. It is often found together with oxidation products (geranial and neral) 12,13 .…”

“…Besides its cosmetic use, geraniol has been shown to have some bioactive properties, including antiinflammatory, anti-angiogenesis, and anti-tumor effects [14][15][16][17][18][19] . The anti-tumor effect of geraniol has been demonstrated in cancer types of various organs such as the liver, lung, pancreas, and colon 12,13,[16][17][18][19][20][21][22] . This mechanism of geraniol, acyclic monoterpenoid alcohol, is by suppresses HMG-CoA reductase activity and stops the growth of co-cultured tumor cells 12,14 .…”