Effect on capillary permeability in rabbits of iridoids from Buddleia scordioides

Abstract

The methanol soluble fraction of the leaves of Buddleia scordioides after column chromatography resulted in the isolation of two known iridoid glucosides, catalpol and methylcatalpol. The structures were elucidated by extensive 1D-2D-NMR spectroscopy. The structure of methylcatalpol was confirmed by single-crystal x-ray diffraction. These compounds showed protective activity against increased (both chloroform and histamine) skin vascular permeability in rabbits. The protective effect was measured as the reduction in leakage of Evans blue. The results showed that the iridoids produced a significant inhibition of microvascular permeability. A comparison was made between the action of the iridoids and a known inhibitor of vascular permeability, troxerutin (50 mg/kg). Methylcatalpol and catalpol were found to be less effective than troxerutin.

Five-year treatment of chronic venous insufficiency with O-(β-hydroxyethyl)-rutosides: Safety aspects

“…The efficacy, tolerability and safety of HR has also been proven (33)(34)(35)(36)(37)(38)(39)(40)42) and confirmed in the present study.…”

“…HR is very effective in treating edema and therefore has a special indication in diabetic patients with CVI. Recent studies (33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47) have also shown the efficacy of HR in CVI for controlling plasma free radicals (9).…”

Metabolites of Rehmannia glutinosa Libosch extract by intestinal bacteria from normal and chronic kidney disease rats in vitro

“…7-10 It can treat a variety of ailments such as diabetes, constipation, urinary tract problems, anemia, dizziness, and regulate menstrual ow. 1,13,14 Acteoside, another main active compound of Rehmannia glutinosa Libosch, shows anti-inammatory and antioxidant potentials. 11 The main active principal is catalpol which is reported to make up 2.7-10.6% of the medicine.…”

Crystal Structure and Conformational Analysis of Iridoid Glycoside Methylcatalpol

“…The methylcatalpol, {1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxyl-methyl)-6-methoxy oxireno [4,5]cyclopenta [1,2c]pyran-2-yl-β-D-glucopyranoside}, which extracted from the leaves of Buddlejadavidii, is a compound belonging to the family of iridoid glycoside. It is a mono-O-methyl derivative of catalpol (Fig.…”

“…). The hydrogen bonds O(5)-H(5)...O(6) and O(7)-H(7)...O(6) form two five-membered rings, respectively. Another six-member hydrogen-bonded ring is also formed through the N(1)-H(1)...O(2) hydrogen bond, with atoms C3, C8 and C9.…”