Effect ofTamarindus indica L. on the bioavailability of aspirin in healthy human volunteers

Garba, M.; Yakasai, I. A.; Bakare, M. T.; Munir, H. Y.

doi:10.1007/bf03189717

Cited by 34 publications

(14 citation statements)

References 2 publications

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“…A clinical study [34] performed on six healthy volunteers showed that a tamarind extract incorporated in a traditional meal increased plasma levels of aspirin and salicylic acid (a metabolite of aspirin). The mechanism of such interaction is not known.…”

Section: Aspirinmentioning

confidence: 99%

Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction

Izzo

Carlo

Borrelli

et al. 2005

International Journal of Cardiology

233

128

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Section: Aspirinmentioning

confidence: 99%

Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction

Izzo

Carlo

Borrelli

et al. 2005

International Journal of Cardiology

233

128

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“…The organic acids and pectin are believed to contribute at least to its laxative effect. With regards to herb–drug interactions, tamarind has been reported to increase the bioavailability of aspirin, leading to gastrointestinal bleeding (16). Whether or not tamarind interacts with other NSAIDs in a similar manner has not yet been documented.…”

Section: Interactions With Tamarind (Tamarindus Indica)mentioning

confidence: 99%

Herbal medication: potential for adverse interactions with analgesic drugs

2002

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The use of herbal supplements in the US has increased dramatically in recent years. These products are not regulated by the Food and Drug Administration (FDA) with the same scrutiny as conventional drugs. Patients who use herbal supplements often do so in conjunction with conventional drugs. This article is a review of potential adverse interactions between some of the commonly used herbal supplements and analgesic drugs. Non-steroidal anti-inflammatory drugs (NSAIDs), particularly aspirin, have the potential to interact with herbal supplements that are known to possess antiplatelet activity (ginkgo, garlic, ginger, bilberry, dong quai, feverfew, ginseng, turmeric, meadowsweet and willow), with those containing coumarin (chamomile, motherworth, horse chestnut, fenugreek and red clover) and with tamarind, enhancing the risk of bleeding. Acetaminophen may also interact with ginkgo and possibly with at least some of the above herbs to increase the risk of bleeding. Further, the incidences of hepatotoxicity and nephrotoxicity may be augmented by acetaminophen when concomitantly used with the potentially hepatotoxic herbs Echinacea and kava, and with herbs containing salicylate (willow, meadowsweet), respectively. The concomitant use of opioid analgesics with the sedative herbal supplements, valerian, kava and chamomile, may lead to increased central nervous system (CNS) depression. The analgesic effect of opioids may also be inhibited by ginseng. It is suggested that health-care professionals should be more aware of the potential adverse interactions between herbal supplements and analgesic drugs, and take appropriate precautionary measures to avoid their possible occurrences. However, as most of the interaction information available is based on individual case reports, animal studies and in vitro data, further research is needed to confirm and assess the clinical significance of these potential interactions.

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“…There are several reports of other commonly consumed supplements with significant effects on drug bioavailability and disposition. For example, kola nut has been reported to cause a significant decrease in the plasma concentration of halofantrine and its metabolite when co‐administered and Tamarindus indica the major component of a local drink widely taken in the Northern part of Nigeria has been reported to significantly decrease the bioavailability of aspirin in healthy human subjects …”

Section: Discussionmentioning

confidence: 99%

Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers

Igbinoba

Onyeji

Akanmu

et al. 2014

The Journal of Clinical Pharma

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We investigated the effect of concurrent ingestion of Garcinia kola seed on the pharmacokinetics of quinine. In a randomized crossover study, 24 healthy Nigerian volunteers were assigned into two groups (A and B; n = 12 per group) on the basis of G. kola dose orally ingested. Each subject received 600mg quinine sulphate before and after ingesting 12.5g of G. kola once daily for seven days (Group A) or 12.5g twice daily for six days and once on the seventh day (Group B). Blood samples were collected and analyzed for plasma quinine and its metabolite, (3-hydroxyquinine) using a validated HPLC method. Concurrent administration of quinine with G. kola reduced quinine tmax by 48% (group A), mean Cmax by 19% and 26% in groups A and B, and slight reduction in mean AUC0–∞ of quinine in both groups. 3-hydroxyquinine Cmax also reduced by 29% and 32%; AUC0–∞ by 13% and 9% respectively. The point estimates of the T/R ratio of the geometric means for all Cmax obtained and only the AUC0–∞ at a higher dose of G. kola were outside the 80–125% bioequivalence range. In conclusion, an herb-drug interaction was noted with concurrent quinine and G. kola administration.

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Effect ofTamarindus indica L. on the bioavailability of aspirin in healthy human volunteers

Cited by 34 publications

References 2 publications

Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction

Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction

Herbal medication: potential for adverse interactions with analgesic drugs

Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers

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