Effect Ofserenoa Repensextract (Permixonr) on Estradiol/Testosterone-Induced Experimental Prostate Enlargement in the Rat

Paubert-Braquet, Monique; Richardson, Fannie O.; Servent-Saez, Nathalie; Gordon, William C.; Monge, Marie-Claude; Bazán, Nicolás G.; Authie, D.; Braquet, P.

doi:10.1006/phrs.1996.0085

Cited by 42 publications

(17 citation statements)

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“…A similar finding was also reported in an in vivo animal study in an elegant model of BPH, in which the drug unequally reduced the weight of the different prostate lobes [42]. Fig.…”

Section: Discussionsupporting

confidence: 69%

Effects of long-term treatment withSerenoa repens (Permixon®) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia

et al. 1998

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“…A similar finding was also reported in an in vivo animal study in an elegant model of BPH, in which the drug unequally reduced the weight of the different prostate lobes [42]. Fig.…”

Section: Discussionsupporting

confidence: 69%

Effects of long-term treatment withSerenoa repens (Permixon®) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia

et al. 1998

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“…Nevertheless, the effects of T and DHT on prostatic growth in rodents have previously been documented and used to assess the effects of drugs used for BPH treatment, including saw palmetto fruit lipid extract. 17,28 In the present study, in rats injected with T, prostatic weight and prostatic/ body weight ratio were decreased after 14 days of oral treatment with D-004 with respect to positive controls. Because D-004 at any of the doses studied did not affect body weight, its effect on the prostatic/body weight ratio was likely a result of preventive effects of D-004 on PH.…”

Section: Discussionsupporting

confidence: 51%

Effects of D-004, a lipid extract from Cuban royal palm fruit, on inhibiting prostatic hypertrophy induced with testosterone or dihydrotestosterone in a rat model: A randomized, controlled study

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et al. 2004

Current Therapeutic Research

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Background: Benign prostatic hypertrophy is the nonmalignant, uncontrolled growth of prostatic epithelial cells and stroma that, left untreated, may lead to difficult urination and other complications. A common treatment of BPH is lipid extract from saw palmetto fruit, and lipid extract from Cuban Royal palm (a palm of the same family) fruit is being studied for this use. One study found that the latter, D-004, at 100 to 400 mg/kg daily prevented prostatic hypertrophy (PH) induced with testosterone (T) in a rat model. Objectives:This study comprised 2 experiments in a rat model. The first assessed the effects of different doses of D-004 on T-induced PH; the second investigated the effects of D-004 on PH induced with dihydrotestosterone (DHT). Methods:In experiment 1, rats were distributed in 6 groups of 10 rats each. One group received an SC injection of soy oil and oral treatment with Tween 65/ water vehicle (negative control). The other 5 groups received an SC injection of T 3 mg/kg daily and oral treatment with vehicle (positive control) or D-004 at 50, 200, 400, or 800 mg/kg daily suspended in vehicle. In experiment 2, rats were distributed in 3 groups of 10 rats each. A negative control group received treatment as in experiment 1. Positive controls received an SC injection of DHT 1.5 mg/kg and vehicle orally. The third group received an SC injection of DHT and oral treatment with D-004 at 800 mg/kg suspended in vehicle. All treatments were given for 14 days. At sacrifice, prostates were removed and weighed. Mean prostatic weights and prostatic/body weight ratios were calculated.Results: In experiment 1, in the groups receiving D4)04 at 200,400, or 800 mg/kg daily, prostatic weight was significantly lower compared with the positive control group (P < 0.05, P < 0.01, and P < 0.001, respectively); this effect was not seen in the group receiving 50 mg/kg daily. In the groups receiving D-004 at 400 and 800 mg/kg daily, prostatic/body weight ratio was significantly lower compared with positive controls tooth, P < 0.05); this effect was not seen in the groups receiving 50 or 200 mg/kg daily. In experiment 2, prostatic weight and prostatic/body weight ratio Accepted for publication August 31, 2004. in the group receiving D-004 were similar to those of positive controls. Body weight was not affected in any of the groups receiving D-004. Conclusions:This study of rats with T-or DHT-induced PH suggests that D-004 at 200 to 800 mg/kg daily administered orally prevents T-induced PH, and that D-004 at 800 mg/kg daily does not prevent DHT-induced PH. (Curr TherRes Clin Exp. 2004;65:505-514)

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“…It mainly consists of free (90%) and esterified (7%) fatty acids and also contains several sterols such as ␤-sitosterol, campesterol, and stigmasterol, as well as flavonoids and fatty alcohols. In in vitro and in vivo models, LSESr exhibits antiandrogenic and antiestrogenic activities [16][17][18] and inhibits 5␣-reductase type I and type II by a noncompetitive mechanism [19][20][21]. Recently, LSESr was reported to reduce dihydrotestosterone (DHT) levels in the prostates of BPH patients [22] and to decrease prostate volume [23].…”

Section: Introductionmentioning

confidence: 97%

Induction of apoptosis and inhibition of cell proliferation by the lipido-sterolic extract ofSerenoa repens (LSESr, Permixon�) in benign prostatic hyperplasia

et al. 2000

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Effect Ofserenoa Repensextract (Permixonr) on Estradiol/Testosterone-Induced Experimental Prostate Enlargement in the Rat

Cited by 42 publications

References 0 publications

Effects of long-term treatment withSerenoa repens (Permixon®) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia

Effects of long-term treatment withSerenoa repens (Permixon®) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia

Effects of D-004, a lipid extract from Cuban royal palm fruit, on inhibiting prostatic hypertrophy induced with testosterone or dihydrotestosterone in a rat model: A randomized, controlled study

Induction of apoptosis and inhibition of cell proliferation by the lipido-sterolic extract ofSerenoa repens (LSESr, Permixon�) in benign prostatic hyperplasia

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