Effect of γ‐Oryzanol on Serum Lipid Peroxide Level and Clinical Symptoms of Patients with Climacteric Disturbances

Abstract

The effect of y-Oryzanol, ferulic acid esters obtained from rice oil, on climacteric disturbances was studied with special reference to lipid peroxide levels in the sera of patient. 300 mg of y-Oryzanol was administered daily to each patient for 4 to 8 weeks. In 85% of 40 cases the effect on the climacteric disturbance was judged by the Kupperman method to be significant. In patients with climacteric disturbances, serum lipid peroxide levels were high, but were reduced significantly after administration of y-Oryzanol. By its administration, total cholesterol, triglyceride and HDLcholesterol were improved in cases with hyperlipidemia (TC>220 mg/dl, TG>140 mg/dl, HDL-chol.<45 mg/dl). The atherogenic index was also considerably reduced. No side effects and n o particular changes in functional tests were observed.

Redox Homeostasis and Natural Dietary Compounds: Focusing on Antioxidants of Rice (Oryza sativa L.)

“…The fact that these natural compounds, including γ-oryzanol, have been demonstrated as Nrf2 inducers provides new insights into their mechanisms of actions supporting and encouraging their use. Indeed, γ-oryzanol is already used as a prescription drug in Japan to treat various conditions such as hyperlipidemia, irritable bowel syndrome, autonomic ataxia, and menopausal syndrome [ 224 , 225 , 226 ]. Γ-Oryzanol is certainly a promising natural dietary compound, being present in high amounts in the principal grain of human diet.…”

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

“…Cholesterol and rice bran oil (998) ; cholesterol absorption and aortic fatty streaks (348,358) ; lipid metabolism (999) ; autonomic nervous unbalance and menopausal troubles (climacteric disturbance) (999,1000) ; anti-ulcerogenic (1001) ; antioxidant (357,360,1002) ; gene expression and oxidative stress (1003) ; glycaemia control (1004,1005) ; platelet aggregation (1006) ; anxiety and stress ulcer (1001,1007 -1009) Avenanthramides: Anti-inflammatory and anti-atherogenic (368) ; smooth muscle cell proliferation and NO production (1010,1011) ; antioxidant (140,367,369) Saponins (370,1012,1013) : Hypercholesterolaemia (173,374,377,1014) ; lipase activity and fat absorption (1015) ; transcriptional activity of Cu,Zn-SOD gene (1016) ; scavenger and superoxides (1017) ; hypoglycaemia (1018,1019) ; gastric emptying rate and glucose transport across the brush border of the small intestine (1018,1020) ; antifungal (374) ; anti-viral (1021) ; diabetes (1022) ; anti-inflammatory (1019) ; anti-carcinogenic (374) ; tumour growth and cytostatic effect (1013,1023 -1027) ; bile acid binding (cited in Mimaki et al (1013) ); cell-mediated immune system and antibody production (375)…”

“…Cholesterol and rice bran oil ( 998 ) ; cholesterol absorption and aortic fatty streaks ( 348 , 358 ) ; lipid metabolism ( 999 ) ; autonomic nervous unbalance and menopausal troubles (climacteric disturbance) ( 999 , 1000 ) ; anti-ulcerogenic ( 1001 ) ; antioxidant ( 357 , 360 , 1002 ) ; gene expression and oxidative stress ( 1003 ) ; glycaemia control ( 1004 , 1005 ) ; platelet aggregation ( 1006 ) ; anxiety and stress ulcer ( 1001 , 1007 – 1009 )…”

Ethanolic extract of rhizome of Ligusticum chuanxiong Hort. (chuanxiong) enhances endothelium-dependent vascular reactivity in ovariectomized rats fed with high-fat diet

“…[8][9][10][11] Ferulic acid was found to increase the serum level of estrogen, improve menopausal symptoms in postmenopausal rat model or women, and display estrogen-like effect. 12,13 Some of the LC active compounds were found to exhibit vasorelaxation effects in rat isolated aorta. [14][15][16] In addition, LC has been used, alone or in combination with other herbs, for the improvement of menstrual disorders, such as irregular menses, amenorrhoea and dysmenorrhoea.…”