Effect of β2-Adrenoceptor Agonists on Saliva Proteins and Dental Caries in Asthmatic Children

Ryberg, Mats; Möller, Christian; Ericson, Thomas

doi:10.1177/00220345870660082401

Cited by 79 publications

(84 citation statements)

References 25 publications

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“…However, the present investigation has revealed differences in caries prevalence in children with and without asthma. This is in line with previous studies [7][8][9][10][11][12][13], which have shown a correlation between childhood asthma and dental caries. Wogelius et al [24], compared children with asthma-drug use with children without asthma-drug use, and "found no increased risk of dental caries in the deciduous teeth, while in the newly erupted permanent teeth, the risk was increased".…”

Section: Discussionsupporting

confidence: 93%

“…Eloot et al [17] found that neither the length of the disease period in 3 to17-year-old children with asthma nor the medication or the severity of the asthma disease had a significant effect on the risk of developing caries or gingivitis. In studies by Ryberg et al [12,13], however, it was shown that asthmatic children who medicated with β 2 agonists had a decreased saliva secretion rate and increased levels of lactobacilli and mutans streptococci, in addition to more caries lesions, compared with healthy children. Mc Derra et al [8] found that 4-to 10-year-old children with asthma had more plaque, gingivitis and calculus compared with healthy controls.…”

Section: Introductionmentioning

confidence: 97%

“…Some authors have reported a correlation between childhood asthma and dental caries in pre-school children [6][7][8][9][10][11][12][13], while others have found no such connection [14][15][16]. Eloot et al [17] found that neither the length of the disease period in 3 to17-year-old children with asthma nor the medication or the severity of the asthma disease had a significant effect on the risk of developing caries or gingivitis.…”

Section: Introductionmentioning

confidence: 99%

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Oral health in preschool children with asthma

Stensson

Wendt

Koch³

et al. 2008

Int J Paed Dentistry

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Objective. The aim of the present study was to investigate oral health and its determinants in 3-and 6-year-old children with asthma. Methods and Subjects.Caries and gingivitis were examined in 127 asthmatic (all children with asthma in a selected area and born during a specific time period) and 117 matched, healthy control children.The parents were interviewed regarding various oral health-related factors.Results. The mean dfs (± standard deviation) in the 3-year-olds with asthma was 1.4 ± 3.2 compared with 0.5 ± 1.2 in the controls (P < 0.05). The corresponding figures for the 6-year-olds were 2.5 ± 3.9 and 1.8 ± 2.8. The 3-year-old asthmatic children had more gingival bleeding than healthy controls (P < 0.05). There were no significant differences in gingivitis in the 6-year-olds.Asthmatic children reported higher consumption of sugar-containing drinks and were more frequently mouthbreathers than healthy children (P < 0.05). In 3-year-old children with asthma and immigrant background, the mean dfs was higher compared with immigrant children in the control group (P < 0.01). Conclusion.The results indicate that pre-school children with asthma have higher caries prevalence than healthy children. The factors discriminating for caries in asthmatic children are higher intake of sugary drinks, mouthbreathing and immigrant background.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral health in preschool children with asthma

Stensson

Wendt

Koch³

et al. 2008

Int J Paed Dentistry

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“…In our study the group of young adults with asthma had a higher prevalence of caries than the healthy controls. This is in agreement with other studies investigating caries in adult asthmatics, where the asthma groups had higher, but not always statistically significant different DFS scores compared with the control groups [10,25]. However, the differences found in the present study were most pronounced when it came to the prevalence of initial caries lesions.…”

Section: Discussionsupporting

confidence: 93%

Oral health in young adults with long-term, controlled asthma

Stensson

Wendt

Koch³

et al. 2011

Acta Odontologica Scandinavica

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Objectives. The aim of the present investigation was to study oral health in young adults with long-term, controlled asthma. Material and methods. Twenty 18-to 24-year-olds with a mean duration (SD) of asthma disease of 13.5 (5.4) years and 20 matched healthy controls were included. A clinical examination was performed and the prevalence of caries, erosions, gingival inflammation, cervicular fluid, periodontal pockets and plaque formation rate, were registered. The salivary flow rate, numbers of mutans streptococci and lactobacilli in saliva were determined. Plaque pH was measured after a sucrose rinse up to 40 min at two approximal sites. The participants were interviewed regarding dietary and oral hygiene habits. Results. The mean (SD) DFS, including manifest and initial caries, was 8.6 (10.6) in the asthma group and 4.0 (5.2) in the control group (p = 0.09). Initial caries lesions were more common in the asthma group than in the control group, 6.0 (8.1) and 1.3 (2.0 (p = 0.02). The asthma group had more gingivitis (p = 0.01) and lower stimulated salivary rate than the controls (p = 0.01). The asthmatics had also a somewhat, but not statistically significant, lower initial pH value in plaque and more pronounced pH drop compared with the controls. In the asthma group, 65% reported frequent mouthbreathing compared with 10% in the controls (p = 0.01). No differences were found in tooth-brushing and dietary habits between the groups. Conclusions. Young adults with long-term, controlled asthma had more initial caries, more gingival inflammation and lower stimulated salivary secretion rate than individuals without asthma.

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“…Medication may be the most significant source of salivary changes in older adults. Anti-cholinergic sideeffects of antihistamines or anti-depressives may induce xerostomia (Spak et al, 1994), while beta-adrenergic agonists or antagonists may alter the concentrations of proteins secreted by acinar cells (Ryberg et al, 1987;Laurikainen et al, 1988;Nederfors et al, 1994). Medication effects need to be controlled when salivary proteins are studied in relation to oral disease in elderly populations.…”

Section: (D) Long-term Changementioning

confidence: 99%

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Rudney

1995

Critical Reviews in Oral Biology & Medicine

108

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Salivary protein interactions with oral microbes in vitro include aggregation, adherence, cell-killing, inhibition of metabolism, and nutrition. Such interactions might be expected to influence oral ecology. However, inconsistent results have been obtained from in vivo tests of the hypothesis that quantitative variation in salivary protein concentrations will affect oral disease prevalence. Results may have been influenced by choices made during study design, including saliva source, stimulation status, control for flow rate, and assay methods. Salivary protein concentrations also may be subject to circadian variation. Values for saliva collected at the same time of day tend to remain consistent within subjects, but events such as stress, inflammation, infection, menstruation, or pregnancy may induce short-term changes. Long-term factors such as aging, systemic disease, or medication likewise may influence salivary protein concentrations. Such sources of variation may increase the sample size needed to find statistically significant differences. Clinical studies also must consider factors such as human population variation, strain and species differences in protein-microbe interactions, protein polymorphism, and synergistic or antagonistic interaction between proteins. Salivary proteins may form heterotypic complexes with unique effects, and different proteins may exert redundant effects. Patterns of protein-microbe interaction also may differ between oral sites. Future clinical studies must take those factors into account. Promising approaches might involve meta-analysis or multi-center studies, retrospective and prospective longitudinal designs, short-term measurement of salivary protein effects, and consideration of individual variation in multiple protein effects such as aggregation, adherence, and cell-killing.

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Effect of β2-Adrenoceptor Agonists on Saliva Proteins and Dental Caries in Asthmatic Children

Cited by 79 publications

References 25 publications

Oral health in preschool children with asthma

Oral health in preschool children with asthma

Oral health in young adults with long-term, controlled asthma

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

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