Effect of β2-adrenoceptor agonists on plasma potassium and cardiopulmonary responses on exercise in patients with chronic obstructive pulmonary disease

Abstract

When compared to salbutamol 2 mg, fenoterol 2 mg caused more marked hypokalaemia but no significant difference in cardiopulmonary response in patients with COPD during exercise.

Study of serum electrolytes in acute exacerbation of chronic obstructive pulmonary disease patients

“…(Yang et al). 15 Comparing COPD patients with electrolyte disorders and those without any electrolyte imbalance on admission, there was a significant decrease in PH, PaO 2 and oxygen saturation in patients with electrolyte disorders, while there was a significant increase in PaCo 2 . This means that patients with electrolyte disorders, suffer from further deterioration in arterial blood gases than other group without any electrolyte disorders.…”

“…17,15 Treatment with Beta 2 agonists can reduce serum magnesium levels through urinary loss or intracellular shift (Rolla, and Bucca). 18 Intravenous aminophylline therapy has been recorded to cause hypomagnesaemia, hypocalcaemia and hyponatraemia in susceptible individuals by increasing the urinary secretion of these electrolytes, this in turn may cause increased pulmonary irritability and consequently increased risk of exacerbation (Knutsen).…”

“…Hypokalemia in COPD may be attributed to respiratory acidosis and metabolic alkalosis or long standing steroid therapy Saini et al 22 Use of beta 2-adrenoceptor agonist like salbutamol may also contribute to hypokalemia in COPD patients (Yang et al). 15 Moreover, acute respiratory failure associated with hypokalemia was found to have a high mortality rate among the COPD patients (Hussain et al). 23 This may be attributed to cardiac arrhythmias or hampered nerve-muscle conduction.…”

Dyselectrolytaemia in Stable and Acute Exacerbation Chronic Obstructive Pulmonary Disease Patients- A Cross Sectional Study

“…[6] Use of beta 2-adrenoceptor agonists like fenoterol or salbutamol may also contribute to hypokalaemia in COPD patients. [7] Moreover, acute respiratory failure associated with hypokalaemia was found to have a high mortality rate among the COPD patients. [8] High mortality in hypokalaemia may be attributed to cardiac arrhythmias or hampered nerve-muscle conduction.…”

Predictors of Need for Non-Invasive Mechanical Ventilation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

“…The study showed a significantly lower Naand K levels in group II patients and both groups had lower than normal values. This can be attributed to the more use of Beta-2 agonists in the more severe cases, as these medications cause electrolytes disturbances (17) . Moreover, Goli et al, 2016 (18) found significantly lower PH in patients with electrolyte disturbance which is also present in the current study.…”