Effect of β-Nicotinamide Adenine Dinucleotide on Acute Allograft Rejection After Rat Lung Transplantation
Jonas P. Ehrsam,
Jin Chen,
Martina Haberecker
et al.
Abstract:Background.
Acute rejection is still a major limitation for a successful outcome in lung transplantation. Since β-nicotinamide adenine dinucleotide (NAD+) has been shown to have various immunomodulatory properties on the innate and adaptive immune system, we evaluate here a potential protective effect of NAD+ against acute lung rejection.
Methods.
Rat single-lung transplantation was performed in 2 groups (n = 8 per group), using Brown-Norway donors and … Show more
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