Effect of β-glucan on serum level of IL-12, hs-CRP and clinical outcomes in Multiple trauma patients: a prospective randomized study

Fazilaty, Zakyeh; Chenari, Hamid; Shariatpanahi, Zahra Vahdat

doi:10.5505/tjtes.2017.34514

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…Similar results in feeding volume and energy intake were observed in the administration of this supplement for 21 days in critically ill patients 20 . However, studies on the efficacy of probiotics in ICU patients have reported contradictory results, from ineffectiveness and even side effects of probiotics to beneficial effects in improving enteral feeding tolerance, depending on the studied population, cause of hospitalization, product format, and study design 12,21–26 . Given that one of the main reasons for obtaining contradictory results on the efficacy of probiotics was the initial differences in the studied population, the present study was performed only on a population of critically ill patients with similar baseline characteristics, fixing this flaw of the previous studies.…”

Section: Discussionsupporting

confidence: 53%

“…20 However, studies on the efficacy of probiotics in ICU patients have reported contradictory results, from ineffectiveness and even side effects of probiotics to beneficial effects in improving enteral feeding tolerance, depending on the studied population, cause of hospitalization, product format, and study design. 12,[21][22][23][24][25][26] Given that one of the main reasons for obtaining contradictory results on the efficacy of probiotics was the initial differences in the studied population, the present study was performed only on a population of critically ill patients with similar baseline characteristics, fixing this flaw of the previous studies. Unlike previous studies showing equivocal results from probiotic use that were due, in part, to differences in study population, our study groups were statistically comparable.…”

Section: Discussionmentioning

confidence: 99%

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Investigating the effect of oral synbiotic on enteral feeding tolerance in critically ill patients: A double‐blinded controlled clinical trial of gut microbiota

et al. 2022

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Background: Probiotics are beneficial live microorganisms that can modify the gut microbiota. It is assumed that they help improve enteral feeding intolerance (EFI) and nosocomial infections in critically ill patients. The present clinical trial aimed to investigate the efficacy of synbiotics in improving EFI and oropharyngeal aspiration in patients admitted to the intensive care unit (ICU).Methods: This randomized clinical trial was conducted on 105 critically ill patients admitted to the ICU of a tertiary referral hospital affiliated with a medical university. The patients were randomly assigned to either a synbiotic or control group and underwent 7 days of investigation. The primary end point was reduced gastric residual volume, which is suggestive of an improvement in EFI. The secondary end point included requirement for prokinetics, frequency of aspiration, duration of mechanical ventilation, length of ICU stay, and level of consciousness. Results: The present clinical trial showed that synbiotic intervention has resulted in a significantly diminished requirement for prokinetics (P = 0.019), fewer oropharyngeal aspirations (P = 0.01), improved volume of bolus administration, and decreased gastric residual volume during the 7-day follow-up period.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Investigating the effect of oral synbiotic on enteral feeding tolerance in critically ill patients: A double‐blinded controlled clinical trial of gut microbiota

et al. 2022

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“…The full texts of the 33 remaining studies were examined to determine their eligibility, and 10 studies were excluded. Finally, 23 RCTs were selected for systematic review and meta-analysis (16)(17)(18)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). The detailed workflow is shown in Figure 1.…”

Section: Search Resultsmentioning

confidence: 99%

Effects of Oats (Avena sativa L.) on Inflammation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2021

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Background: Oat and its compounds have been found to have anti-inflammatory effects. Through this systematic review and meta-analysis, we aimed to determine an evidence-based link between oat consumption and inflammatory markers.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. By the end of April 2021, we included randomized controlled trials (RCTs) that investigated the anti-inflammatory effect of oat and oat-related products through screening PubMed, Embase, Web of Science, ClinicalTrial.gov, and CENTRAL. Meta-analysis was conducted with a random-effect model on the standardized mean difference (SMD) of the change scores of inflammatory markers, including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8). Subgroup analyses were conducted to stratify confounding variables. The risk of bias was evaluated using the Cochrane risk of bias tool and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) was applied to report the quality of evidence. This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42021245844).Results: Systematic screening of five databases yielded 4,119 studies, of which 23 RCTs were finally selected. For the four systemic inflammatory markers analyzed, no significant alterations were found after oat consumption. However, oat intake was found to significantly decrease CRP levels in subjects with one or more health complications (SMD: −0.18; 95% CI: −0.36, 0.00; P = 0.05; I2 = 10%). Furthermore, IL-6 levels were significantly decreased in subjects with dyslipidemia (SMD = −0.34; 95% CI: −0.59, −0.10; P = 0.006; I2 = 0%). These beneficial effects might be attributed to the effects of avenanthramide and β-glucan.Conclusions: Overall evidence supporting the alleviation of inflammatory response by oat intake was poor, calling for future studies including a larger sample size to confirm the findings.

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“…Malik et al demonstrated that probiotic administration was associated with significantly lower ICU LOS [26]. Other studies found no significant difference between groups, regarding ICU or hospital LOS [19,21,22,24,27,[30][31][32][33].…”

Section: Effect On Length Of Staymentioning

confidence: 99%

“…The number of days of diarrhea was also investigated in two studies, one of which reported a significant decrease [25], while the other found a non-significant increase [28]. The number of liquid stools was also reported to be lower in the prebiotic group in one trial [21].…”

Section: Effect On Diarrheamentioning

confidence: 99%

Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review

et al. 2021

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Purpose The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally fed critically ill adult patients. Methods MEDLINE, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up to November 2019. English language randomized controlled trials reporting the effect of pre, pro or synbiotics on the feeding tolerance of enterally fed critically ill adult patients were included. Results Overall, 15 papers were selected for review. Among six studies reporting the energy intake, only two studies showed significantly higher energy intake in the prebiotic-receiving groups. Among four RCTs reporting frequency or time to achieve the target calorie, only one found a significant effect of probiotics to reduce the time to achieve a target dose of calorie. About the prevalence or duration of diarrhea, 7 out of 12 RCTs reported a beneficial effect. All but one study found no beneficial effects for gut microbiota manipulation on clinical endpoints including length of stay (LOS) in hospital and intensive care unit (ICU). Conclusion It should be noticed that the heterogeneity in study designs, product format, and ICU patient populations makes it difficult to draw any general conclusion. Overall, it seems that pre, pro, or synbiotics have no significant beneficial effect on feeding tolerance and clinical endpoints in critically ill adults, but they may reduce the prevalence or duration of diarrhea.

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Effect of β-glucan on serum level of IL-12, hs-CRP and clinical outcomes in Multiple trauma patients: a prospective randomized study

Abstract: ß-glucan may increase serum levels of IL-12, shorten the duration of mechanical ventilation, and reduce organ failure in critically ill multiple-trauma patients.

Cited by 7 publications

References 41 publications

Investigating the effect of oral synbiotic on enteral feeding tolerance in critically ill patients: A double‐blinded controlled clinical trial of gut microbiota

Investigating the effect of oral synbiotic on enteral feeding tolerance in critically ill patients: A double‐blinded controlled clinical trial of gut microbiota

Effects of Oats (Avena sativa L.) on Inflammation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review

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