Effect of β-casomorphines on mother-oriented (“Child’s”) behavior of white rats

Дубынин, В. А.; Ivleva, Y. A.; Stovolosov, I.S.; Belyaeva, Yu A; Dobryakova, Yu. V.; Андреева, Л. А.; Alfeeva, L. Yu.; Каменский, А. А.; Myasoedov, N. F.

doi:10.1134/s0012496607010012

Cited by 7 publications

(9 citation statements)

References 12 publications

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“…The mechanisms of these changes require further investigations. They are probably related to differences in the number and localization of D 1 and D 2 receptors on forebrain neurons (e.g., in the ventral striatum) [1].…”

Section: Resultsmentioning

confidence: 99%

“…The subthreshold dose of D 1 receptor antagonist SCH23390 was similar for 10-dayold and 15-day-old rat pups (0.01 mg/kg). The dose of β-casomorphin-7 (5 mg/kg) was selected from the results of our previous experiments [1].…”

Section: Resultsmentioning

confidence: 99%

“…Administration of this peptide in a dose not affecting locomotor activity was shown to increase maternal bonding. It should be emphasized that the effect of β-casomorphin-7 became more pronounced with an increase in the age of animals [1]. Here we studied whether β-casomorphin-7 can abolish the inhibitory effect of clebopride.…”

Section: Resultsmentioning

confidence: 99%

“…The neurochemical basis of "child's" (maternal bonding) behavior is provided by oxytocin, opioid peptides, and catecholamines [10,13]. Opioid receptor agonists (morphine and β-casomorphins) and antagonists increase and decrease the corresponding reactions, respectively [1,3]. μ-Opioid receptorknockout newborn mice practically do not respond to maternal odor [7].…”

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confidence: 99%

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Role of the Brain Dopaminergic and Opioid System in the Regulation of “Child’s” (Maternal Bonding) Behavior of Newborn Albino Rats

2011

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Administration of D(2) receptor antagonist clebopride in a dose not affecting locomotor activity was followed by a decrease in maternal bonding behavior of 10-day-old and 15-day-old albino rat pups. D(1) receptor antagonist SCH23390 had a stimulatory effect only on the behavior of 10-day-old newborns. Opioid peptide β-casomorphin-7 abolished the effect of clebopride in rat pups of the older age group.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Role of the Brain Dopaminergic and Opioid System in the Regulation of “Child’s” (Maternal Bonding) Behavior of Newborn Albino Rats

2011

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“…Under normal conditions, in an adult mammal, opioid peptides from the gastrointestinal tract do not penetrate into the central nervous system. Opioid receptors located in the wall of the stomach and intestines can bind to these opioid ligands to induce local and behavioral effects (Dubynin et al, 2004(Dubynin et al, , 2007Belyaeva et al, 2008;Yoshikawa, 2015). Thus, orally ingested soymorphin has been found to suppress food intake by activating mu opioid receptors in the gastrointestinal tract (Kaneko et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior

Sudakov

Bogdanova

2021

Front. Behav. Neurosci.

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The involvement of peripheral opioid receptors in the mechanisms of eating behavior is still unclear. The aim of this work was to study the role of peripheral, predominantly gastric mu and delta opioid receptors in the realization of food motivation in conditions of different energy costs for eating behavior. Experiments were performed under a between-sessions progressive ratio schedule of reinforcement in food-deprived rats. The level of food motivation was calculated using a self-developed method. Food intake, motor activity, and metabolic rate were recorded in fed and hungry animals. Results showed that intragastric administration of the mu opioid receptor agonist DAMGO led to an increase in the level of food motivation in the light variant of operant feeding behaviors. Food consumption did not change. At high costs for feeding behavior, the administration of DAMGO did not alter food motivation; however, food consumption and motor activity were reduced. Intragastric administration of the delta opioid receptor agonist DADLE did not lead to changes in the level of food motivation and physical activity, but inhibition of feeding behavior was observed in all reinforcement schedules. Three regulatory pathways of eating behavior in difficult food conditions by peripheral, predominantly gastric opioid receptors are hypothesized: environmental-inhibitory afferentations and suppression of the realization of food motivation into behavior; homeostatic-inhibitory action on food motivation; and rewarding-suppression of the anticipatory reinforcement.

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A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

et al. 2021

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Purpose Food-derived bioactive peptides may influence important physiological functions. An important example is beta-casomorphins, which are opioid peptides derived from A1 beta-casein in bovine milk and have been associated to be risk factors for non-communicable diseases in humans. A1 and A2 beta-casein are different with respect to the release of bioactive peptides, in particular BCM-7. However, evidence from human studies is limited and could be complemented with evidence derived from animal studies. We conducted a scoping review to identify animal studies investigating the effects of A1 beta-casein or BCM-7 compared to A2 beta-casein or any other intervention on health-related outcomes. Methods We systematically searched for relevant studies in two electronic databases (Medline, Embase; last search performed March 2020). Two reviewers independently undertook study selection and data extraction of included references. Results were summarized tabularly and narratively. Results We included 42 studies investigating various animal models, including rats, mice, rabbits, and dogs. Six studies investigated health-related outcomes of A1- vs. A2 milk, while most studies (n = 36) reported on physiological properties (e.g., analgesic effect) of BCM-7 as an opioid peptide. Included studies were extremely heterogeneous in terms of the study population, type of intervention and dose, and type of outcome measures. Conclusions Only a few studies comparing the effects of A1- and A2 milk were identified. More studies addressing this research question in animal models are needed to provide essential information to inform research gaps. Results from future studies could eventually complement research for humans, particularly when the body of evidence remains uncertain as is the case in the A1- and A2 milk debate.

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Effect of β-casomorphines on mother-oriented (“Child’s”) behavior of white rats

Cited by 7 publications

References 12 publications

Role of the Brain Dopaminergic and Opioid System in the Regulation of “Child’s” (Maternal Bonding) Behavior of Newborn Albino Rats

Role of the Brain Dopaminergic and Opioid System in the Regulation of “Child’s” (Maternal Bonding) Behavior of Newborn Albino Rats

Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior

A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

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