Effect of α2A-adrenoceptor C-1291G genotype and maltreatment on hyperactivity and inattention in adolescents

Kiive, Evelyn; Kurrikoff, Triin; Mäestu, Jarek; Harro, Jaanus

doi:10.1016/j.pnpbp.2009.11.011

Cited by 28 publications

(25 citation statements)

References 41 publications

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“…Because Closeness and Support and Misprize and Abuse appear related to each other, their scores can be combined into higher order subscales Warmth in the Family and Maltreatment, respectively (Paaver et al 2008;Kiive et al 2010). Additionally, the Parent Acceptance-Rejection/Control Questionnaire: Mother (Short Form) was used to assess family relationships (Rohner 2005).…”

Section: Stressful Life Events and Family Environmentmentioning

confidence: 99%

A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity

et al. 2010

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This study provides further evidence that short alleles of NOS1 ex1f-VNTR go along with impulsive behavior. In the absence of adverse environmental conditions, this may lead to a beneficial effect as functional forms of impulsivity are affected. This however is reversed under negative conditions, as dysfunctional impulsivity is increased under these circumstances. This data provides evidence that NOS1 ex1f-VNTR is subject to balancing selection potentially explaining persistence of the risk allele in the population.

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Section: Stressful Life Events and Family Environmentmentioning

confidence: 99%

A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity

et al. 2010

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“…Although studies of parenting and its interaction with child genotype for ADHD are still in their infancy , G×E effects have also been reported for prenatal exposure to teratogens (Kahn et al 2003) and maltreatment (Kim-Cohen et al 2006;Klive et al 2010), with the most robust G×E effects observed for aspects of the family environment (e.g., parenting, family/marital conflict). Evidence of G×E between parenting and child genotype for EB may be relevant to G×E studies of ADHD given evidence that the covariation between ADHD and EB reflects common genetic factors (Burt et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype

Lee

2011

J Abnorm Child Psychol

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Relatively little is known about the potential interplay between genetic and environmental influences on attention-deficit/hyperactivity disorder (ADHD), including gene-environment interaction (G×E). There is evidence that parenting behavior interacts with offspring genotype in the development of externalizing problems, but studies have largely focused on explicit maltreatment rather than differentiated measures of parenting behavior, including positive and negative parenting. We tested the interactive effects of the 30-base pair variable number tandem repeat (VNTR) polymorphism of the monoamine oxidase A gene (MAO-A) with positive and negative parenting behavior on parent- and teacher ratings of inattention and hyperactivity symptoms among 150 6-9 year-old boys with and without ADHD. Negative parenting predicted parent and teacher ratings of inattention symptoms, but only among boys with high-activity MAO-A genotype. MAO-A genotype did not moderate the association of positive parenting and parent- and teacher ratings of ADHD. We discuss the potential role of interactive exchanges between parenting behavior and child genotype in the development and persistence of ADHD and related behavior problems.

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“…On the contrary, in subjects with Tourette syndrome, the C allele has been in a co-dominant manner (CC > CG > GG) associated with symptoms of addiction (Comings et al 2003). The ADRA2A C-1291G genotype has been associated with symptoms of childhood attention-deficit hyperactivity disorder (ADHD; Kiive et al 2010;Park et al 2005;Roman et al 2003Roman et al , 2006Schmitz et al 2006) which is often co-morbid with, or predictive of, later substance use (Barkley et al 2004;Looby 2008;Molina and Pelham 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of the serotonin transporter (5-HTTLPR) and α2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study

et al. 2010

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Effect of α2A-adrenoceptor C-1291G genotype and maltreatment on hyperactivity and inattention in adolescents

Cited by 28 publications

References 41 publications

A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity

A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity

Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype

Effects of the serotonin transporter (5-HTTLPR) and α2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study

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