Effect of (-)-α-Bisabolol on the Inflammatory Response in Systemic Infection Experimental Model in C57BL/6 Mice

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

“…Herein, the anti-inflammatory activities of MOEE are possibly attributed to its constituents of bisabolol, thymol, caryophyllene, and eugenol. Fontinele et al [84] and Cavalcante et al [85] demonstrated that treatment with (-)-α-bisabolol reduced the inflammation in inflammatory pain and systemic infection experimental models in mice by the modulation of the release of pro-and anti-inflammatory cytokines and reducing NO production. It significantly prevented the increase of MPO activity, TNF-α, and inducible nitric oxide synthase (iNOS) production in permanent focal cerebral ischemia [86].…”

Chamomile as a potential remedy for obesity and metabolic syndrome

“…The main biological and pharmacological properties of chamomile include antioxidant (Cemek et al, 2008[ 18 ]; Capuzzo et al, 2014[ 15 ]; Kolodziejczyk-Czepas et al, 2015[ 64 ]; Stanojevic et al, 2016[ 125 ]; Jabri et al, 2017[ 55 ], 2020[ 54 ]), anti-inflammatory (Bhaskaran et al, 2010[ 12 ]; Miguel et al, 2015[ 90 ]; Cavalcante et al, 2020[ 17 ]), antimicrobial (Kazemi, 2015[ 60 ]; Stanojevic et al, 2016[ 125 ]), antispasmodic (Albrecht et al, 2014[ 2 ]; Gentile et al, 2018[ 40 ]) and sedative (Amsterdam et al, 2009[ 4 ]) activities.…”

“…The anti-inflammatory effects of chamomile preparations or their isolated compounds have been identified in studies of multiple experimental models (Miguel et al, 2015[ 90 ]; Wang et al, 2020[ 138 ]; Cavalcante et al, 2020[ 17 ]) and when used to treat various diseases associated with the development and progression of inflammatory processes (Jabri et al, 2020[ 54 ]; Wang et al, 2020[ 138 ]). For example, treatment of macrophages with lipopolysaccharide (LPS) from Escherichia coli is a well-established experimental system for studies of inflammation and stimulates a range of signaling pathways, including NF-κB-mediated signaling that enhances the transcription of mRNA encoding pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α (Tanaka et al, 2014[ 130 ]).…”

“…Such effects are likely to be due to blocking the activation of the pro-inflammatory signaling cascade mediated by NF-κB (Kim et al, 2011[ 62 ]; Bhaskaran et al, 2010[ 12 ]; Ma et al, 2020[ 80 ]). In addition to flavonoids, components of essential oils like bisabolol, chamazulene and farnesene were shown to possess anti-inflammatory properties (Cavalcante et al, 2020[ 17 ]; Wang et al, 2020[ 139 ]).…”

“…Individual essential oils from chamomile flowers have not been studied as anti-obesity agents but some studies reported anti-inflammatory effects of the chamomile sesquiterpenes α-bisabolol and chamazulene in experimental models of inflammation (Rocha et al, 2011[ 111 ]; Fernandes et al, 2019[ 34 ]; Cavalcante et al, 2020[ 17 ]; Ma et al, 2020[ 80 ]). In addition, antioxidant activity of α-bisabolol and chamazulene was demonstrated in both in vitro and in vivo studies (Capuzzo et al, 2014[ 15 ]; Querio et al, 2018[ 105 ]; Wang et al, 2020[ 139 ]; Cavalcante et al, 2020[ 17 ]). In particular, chamazulene attenuated ROS production in bovine aortic endothelial cells treated with either high glucose or H 2 O 2 (Querio et al, 2018[ 105 ]).…”