Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats

Mohammadifar, Mojgan; Taghizadeh, Mohsen; Abed, Alireza; Soltani, Ali; Tamtaji, Omidreza; Khamechian, Tahere; Hatami, Alireza; Talaei, Sayyed Alireza

doi:10.29252/jmp.4.72.s12.133

Cited by 5 publications

(8 citation statements)

References 36 publications

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“…The hepatoprotective properties of extracts from various morphological parts of C. intybus have been confirmed in recent years by many authors [ 47 , 48 , 49 , 50 , 51 ]. One study, which used mice with liver previously damaged with acetaminophen and carbon tetrachloride, demonstrated, that application of a aqueous- and methanolic chicory seed extract to the animals lowered their mortality, as well as serum levels of alkaline phosphatase (AP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT).…”

Section: Health-promoting Propertiesmentioning

confidence: 84%

The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties—A Review

et al. 2021

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Natural products are gaining more interest recently, much of which focuses on those derived from medicinal plants. The common chicory (Cichorium intybus L.), of the Astraceae family, is a prime example of this trend. It has been proven to be a feasible source of biologically relevant elements (K, Fe, Ca), vitamins (A, B1, B2, C) as well as bioactive compounds (inulin, sesquiterpene lactones, coumarin derivatives, cichoric acid, phenolic acids), which exert potent pro-health effects on the human organism. It displays choleretic and digestion-promoting, as well as appetite-increasing, anti-inflammatory and antibacterial action, all owing to its varied phytochemical composition. Hence, chicory is used most often to treat gastrointestinal disorders. Chicory was among the plants with potential against SARS-CoV-2, too. To this and other ends, roots, herb, flowers and leaves are used. Apart from its phytochemical applications, chicory is also used in gastronomy as a coffee substitute, food or drink additive. The aim of this paper is to present, in the light of the recent literature, the chemical composition and properties of chicory.

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Section: Health-promoting Propertiesmentioning

confidence: 84%

The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties—A Review

et al. 2021

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“…8,25 In previous studies, its effect on NAFLD was demonstrated in vivo. 26,27 The activity of C. intybus seed ethanolic extract on hepatic steatosis induced by diabetes mellitus and bovine serum albumin-oleic acid complex in HepG2 cells was evaluated. The expression levels of SREBP-1c and PPAR-α were determined.…”

Section: Cassia Obtusifolia (L)hs Irwin and Barnebymentioning

confidence: 99%

“…: Its effects against fatty liver were proven in many experimental studies. 26,59 In addition to its extract, there is a lot of scientific evidence on the effect of silybin and silymarin against fatty liver. 36…”

Section: Cassia Obtusifolia (L)hs Irwin and Barnebymentioning

confidence: 99%

Herbal Preparations Used Against Fatty Liver Disease: Systematic Review

Karadağ¹,

Demirci²

2022

J Lit Pharm Sci

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“…In traditional medicine, Silybum marianum powder or extract is used in the treatment of liver disorders, cardiovascular disease, and hypolipidemia (15). Many reports have shown that the use of silymarin can exert positive effects on reducing drug resistance (15,16).…”

Section: Introductionmentioning

confidence: 99%

“…Milk thistle is a plant that is known as an increaser of bile flow (17). Its extract contains various chemicals, including flavonolignans, which are collectively called silymarin (16). Silymarin is a mixture of flavonoids that have been proven to have hepatoprotective and antioxidant effects.…”

Section: Introductionmentioning

confidence: 99%

Effect of Livergol on the Liver Function and its Histopathological Changes in Doxorubicin-Treated Rats

2023

ircmj

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Background: Doxorubicin (DOX) is an effective anti-cancer medicine with serious side effects on healthy organs, especially the liver. Objectives: The present study aimed to investigate the histopathology and effects of Livergol (Liv), a product of Silybum marianum, on serum levels of hepatic parameters in long-term DOX-treated rats. Methods: Sixty three male Wistar rats were divided into seven groups, namely the control, sham, and experimental groups 1-5, which received certain doses of DOX, Liv, and their combination for 2 months. To produce a cumulative dose, 10 doses of 2 mg/kg DOX were intraperitoneally administered once every 6 days. Moreover, 150 and 300 mg/kg daily doses of Liv were gavaged to the experimental groups 2-5. In addition, blood samples were taken, serum levels of hepatic functional factors and liver enzymes were measured, and hematoxylin-eosin staining was performed to evaluate liver histopathology. The results were analyzed between experimental and control groups by analysis of variance and Tukey tests and the significance level was considered at < 0.05. Results: The serum levels of triglyceride, cholesterol, low-density lipoprotein, total and direct bilirubin, and liver enzymes in the DOX + Liv300 and Liv150 groups showed a significant decrease, compared to the DOX group. While high-density lipoprotein, albumin, and total protein showed a significant increase. Liver tissue in DOX + Liv300 and Liv150 groups did not show any damage. In addition, the serum level of liver enzymes, lipid profile, biochemical factors, and liver histopathology in the Liv300 and Liv150 groups were similar to those in the control group. Conclusion: The findings demonstrated that the oral administration of Liv powder can prevent liver side effects of DOX in rats.

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Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats

Cited by 5 publications

References 36 publications

The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties—A Review

The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties—A Review

Herbal Preparations Used Against Fatty Liver Disease: Systematic Review

Effect of Livergol on the Liver Function and its Histopathological Changes in Doxorubicin-Treated Rats

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