Effect of zinc supplementation on plasma levels of vitamin a and retinol-binding protein in malnourished children

Shingwekar, A G; Mohanram, M.; Reddy, Vinodini

doi:10.1016/0009-8981(79)90249-3

Cited by 55 publications

(13 citation statements)

References 9 publications

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“…Consequently, other antioxidant compounds, such as vitamins C, E, and A, would be protected from oxidation and therefore would have higher serum concentrations in animals supplemented with lycopene compared with animals receiving no lycopene, as observed in our study. This phenomenon has previously been observed by others (67,68). An alternative explanation is the increased food intake by animals receiving lycopene (see Table 4), which may have provided them with more antioxidant vitamins.…”

Section: Figurementioning

confidence: 63%

Lycopene Supplementation Prevents the Development of Spontaneous Smooth Muscle Tumors of the Oviduct in Japanese Quail

Şahin¹,

Ozercan²,

Onderci³

et al. 2004

Nutrition and Cancer

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Leiomyomas (fibroids) are benign tumors of the uterus affecting millions of women. Spontaneous leiomyomas of the oviduct are common tumors of the Japanese quail (Coturnix coturnix japonica), which makes it a good animal model for screening potential agents for testing in the prevention and treatment of human myoma uteri. Because dietary intake of lycopene has been associated with a reduced risk of a variety of human cancers, we investigated the effects of lycopene supplementation on the development of leiomyomas in the oviduct of Japanese quail. We also measured serum levels of oxidative stress markers [malondialdehyde (MDA) and homocysteine], lycopene, vitamins C, E, and A, and tissue biomarkers Bcl-2 and Bax expression. One hundred twenty quails (6 mo old) were assigned to 3 treatment groups consisting of 4 replicates of 10 birds in each group. Birds were fed either a basal diet (group C) or the basal diet supplemented with 100 mg (group L1) or 200 mg (group L2) of lycopene per kilogram of diet. The animals were sacrificed after 285 days and the tumors were identified. Lycopene supplementation decreased the number of leiomyomas compared with control subjects (P=0.056). The tumors in lycopene-fed birds were smaller than those found in control birds (P=0.01). There were no significant differences in the expression of tissue Bcl-2 and Bax among the study groups. Serum vitamins C, E, and A increased (P=0.01), whereas MDA and homocysteine concentrations decreased (P=0.01) with lycopene supplementation. No measurable lycopene could be detected in the serum of control birds, whereas a dose-dependent increase was observed in the serum of lycopene-supplemented birds. The results indicate that dietary supplementation with lycopene reduces the incidence and size of spontaneously occurring leiomyoma of the oviduct in the Japanese quail. Clinical trials should be conducted to investigate the efficacy of lycopene supplementation in the prevention and treatment of uterine leiomyoma in humans.

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Section: Figurementioning

confidence: 63%

Lycopene Supplementation Prevents the Development of Spontaneous Smooth Muscle Tumors of the Oviduct in Japanese Quail

Şahin¹,

Ozercan²,

Onderci³

et al. 2004

Nutrition and Cancer

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“…Vitamin A de®ciency is a cause of nutritional anaemia (Shingwekar et al, 1979). Hodges found in 1971 that volunteers on a prolonged vitamin A-de®cient diet anaemia that responded to vitamin A but not to iron (Hodges & Kolerd, 1971).…”

Section: Discussionmentioning

confidence: 99%

“…A study from India among malnourished children supports this concept. The children showed a signi®cant increase of plasma vitamin A and retinol-binding protein in response to zinc supplementation (Shingwekar et al, 1979). In a study performed in Thailand, no effect on retinol binding protein or serum retinol was noted when zinc was added to the vitamin A supplementation as compared to a group of children who received vitamin A alone (Udomkesmalee et al, 1992).…”

Section: Introductionmentioning

confidence: 97%

Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh

et al. 1999

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Objective: The study was set up to determine to what extent the addition of a supplement of vitamin A alone or in combination with zinc would improve standard iron treatment and correction of iron de®ciency anaemia. Design: 216 non-pregnant anaemic women of 15 ± 45 years of age with haemoglobin levels 100 gal were randomly assigned to three treatment groups. One group (A) received iron alone, a second group (B) received iron and vitamin A, and a third group (C) received iron, vitamin A and zinc. Every woman was given one iron capsule per day for 60 days as FeSO 4 containing 60 mg of elemental iron. In addition, groups B and C received 200 000 IU of vitamin A, given as a supervised dose, on the ®rst day of the treatment after collection of the blood sample. Group C received one zinc tablet per day for 60 days as zinc gluconate containing 15 mg of elemental zinc. Setting: The north-western part of Bangladesh in the urban slums of Dinajpur district between February and August 1995. Subjects: To select women with a haemoglobin level of 100 gal, all the women of four randomly selected municipal slums of the district in the targeted age group (328) were invited to take part in the study. Blood samples were analysed for haemoglobin, serum iron, total iron binding capacity (TIBC), ferritin, retinol and zinc. Results: Out of the 328 women screened, 254 (77.5%) had a haemoglobin level 100 gal and 322 (98%) 120 gal. The three treatment schedules signi®cantly increased haemoglobin levels and improved iron parameters, except for serum iron in the group who received iron alone. The group who received iron, vitamin A and zinc responded best with an increase in haemoglobin of 17.9 gal as compared to the group receiving iron alone (13.4 gal). Iron and vitamin A treatment gave an intermediate response of 15.9 gal. However, these differences are only statistically signi®cant only for the group who received iron, vitamin A and zinc and only for the increase in haemoglobin, P 0.03. Conclusion:The results are suggestive that the addition of vitamin A and zinc to the treatment for anaemia can increase haemoglobin levels more than with iron alone. Sponsorship: The present study was ®nanced by grant FWO 1.5.092.96 and Nutrition Tiers Monde.

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“…93,94 This discrepancy from the other 2 trials 95,96 may be related to baseline nutritional status, as the effect of zinc supplementation was greater in children deficient in zinc or VA, and previous research supports an effect primarily among children with moderate to severe protein energy malnutrition and/or low baseline zinc status. 93,97 Detection and Consequences of VA Toxicity Hypervitaminosis A is an issue of potential concern in low-and middle-income countries, where children may be exposed to multiple VA interventions, including high-dose supplements, fortified foods, and, to a lesser extent, MNP.…”

Section: Current Limitations Of the Isotope Dilution Techniquementioning

confidence: 99%

Current Capabilities and Limitations of Stable Isotope Techniques and Applied Mathematical Equations in Determining Whole-Body Vitamin A Status

et al. 2016

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Background: Retinol isotope dilution (RID) methodology provides a quantitative estimate of total body vitamin A (VA) stores and is the best method currently available for assessing VA status in adults and children. The methodology has also been used to test the efficacy of VA interventions in a number of low-income countries. Infections, micronutrient deficiencies (eg, iron and zinc), liver disease, physiological age, pregnancy, and lactation are known or hypothesized to influence the accuracy of estimating total body VA stores using the isotope dilution technique. Results: Various equations and compartmental modeling have been used to estimate the total body VA stores using stable isotopes, including a newer 3-day equation that provides an estimate of total body VA stores in healthy adults. At present, there is insufficient information on absorption of the isotope tracer, and there is a need to further investigate how various factors impact the application of RID techniques in field studies. Conclusions: Isotope dilution methodology can provide useful estimates of total body VA stores in apparently healthy populations under controlled study conditions. However, more research is needed to determine whether the method is suitable for use in settings where there is a high prevalence of infection, iron deficiency, and/or liver disease.

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Effect of zinc supplementation on plasma levels of vitamin a and retinol-binding protein in malnourished children

Cited by 55 publications

References 9 publications

Lycopene Supplementation Prevents the Development of Spontaneous Smooth Muscle Tumors of the Oviduct in Japanese Quail

Lycopene Supplementation Prevents the Development of Spontaneous Smooth Muscle Tumors of the Oviduct in Japanese Quail

Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh

Current Capabilities and Limitations of Stable Isotope Techniques and Applied Mathematical Equations in Determining Whole-Body Vitamin A Status

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