Effect of zinc supplementation on serum biochemicals in grower pig

Abstract

Zinc (Zn) has a wide spectrum of biological activities, and its deficiency has been related to various dysfunctions and alterations of normal cell metabolism. To compare the effect of a higher dose of Zn supplementation on serum biochemicals of grower pigs (four months of age) that may serve as general indicators of optimum physiological functions, an experiment was conducted with one treatment group supplemented with higher dose of Zn (500 ppm) and another made deficient by supplementing calcium carbonate (CaCO 3) at 1.5% of dry matter of diet, for a period of four months, and was compared to the control supplemented with 100 ppm Zn. Serum Zn decreased significantly in a deficient group (p B0.01), and the animals developed clinical symptoms of parakeratosis. Total serum protein and haemoglobin (Hb) concentration revealed a significantly (p B0.01) increasing trend in Zn-supplemented (500 ppm) animals from day 45 of treatment, whereas a significantly (p B0.01) decreasing trend was observed in deficient pigs. Serum albumin level was not affected by different supplemental level of Zn or induced Zn deficiency. An apparent increasing trend of glucose and cholesterol level was recorded in supplemented groups. However, it decreased significantly (p B 0.01) in deficient pigs. The higher serum concentration of Zn, total serum protein, glucose, cholesterol andHb, resulting from 500 ppm of Zn supplementation in grower pigs, might help in maintaining a better physiological status through promotion of well-organised vital functions of proteins, ensuring a sufficient energy source for different physiological processes, and just source for synthesis of steroid hormones and optimal functioning of membrane receptors.

Metabolomics revealed diurnal heat stress and zinc supplementation-induced changes in amino acid, lipid, and microbial metabolism

“…The lack of diet‐induced changes in serum Zn level could be due to the facts: (1) the Zn supplementation in this study adopted a more physiologically relevant dose and a shorter duration compared with other Zn supplementation experiments that increased serum Zn level (Schell and Kornegay ; Borah et al. ); and (2) there exists robust regulation of Zn homeostasis in the body (King et al. ).…”

“…Targeted analyses of specific metabolites have been performed in numerous studies on HS exposure and Zn supplementation (Baumgard and Rhoads ; Borah et al. ; Belhadj Slimen et al. ).…”

“…2A-E). The lack of diet-induced changes in serum Zn level could be due to the facts: (1) the Zn supplementation in this study adopted a more physiologically relevant dose and a shorter duration compared with other Zn supplementation experiments that increased serum Zn level (Schell and Kornegay 1996;Borah et al 2014); and (2) there exists robust regulation of Zn homeostasis in the body (King et al 2000). Previous studies have shown that serum and whole-body Zn levels in humans and animals are relatively stable even under a wide range of dietary Zn intake, since higher Zn intake is commonly translated into reduced absorption efficiency and higher fecal excretion Kirchgessner 1978, 1980;Cragg et al 2005).…”

“…Targeted analyses of specific metabolites have been performed in numerous studies on HS exposure and Zn supplementation (Baumgard and Rhoads 2013;Borah et al 2014;Belhadj Slimen et al 2015). Despite their merits in confirming expected metabolic changes or revealing general metabolic status of study subjects, targeted analyses are incapable of defining global profile of metabolic system or identifying unexpected metabolic events.…”

Efecto del consumo de zinc orgánico en la respuesta productiva de la cerda y su camada

“…Es un mineral traza con demostrada importancia para la función de más de 300 enzimas (Bhowmik et al, 2010;Chasapis et al, 2012), influyendo en el equilibrio ácido-base, la competencia inmune y las funciones celulares básicas (Haase y Rink, 2009a;Kelleher et al, 2011). La acción metabólica del Zn incluye el metabolismo energético, la síntesis de proteínas, metabolismo de los ácidos nucleicos, la integridad del tejido epitelial, la reparación y la división celular, transporte y utilización de la vitamina A, y la absorción de vitamina E (Bhowmik et al, 2010;Borah et al, 2014).…”