Effect of Zinc Supplementation on Hyperprolactinaemia in Uraemic Men

Mahajan, S K; Flamenbaum, Walter; Hamburger, RobertJ.; Prasad, A S; Mcdonald, FranklinD.

doi:10.1016/s0140-6736(85)90630-0

Cited by 31 publications

(11 citation statements)

References 21 publications

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“…Experimental and clinical studies have suggested that a zinc deficiency may be associated with hyperprolactinemia and gonadal dysfunction [14]. On the other hand, some researchers have documented that hypozincemia is uncom mon in uremic patients and that gonadal disorders are not corrected after zinc supplementation [15].…”

Section: Discussionmentioning

confidence: 99%

Effect of Clomiphene Citrate on Hormonal Profile in Male Hemodialysis and Kidney Transplant Patients

Martín‐Malo

Benito

Castillo

et al. 1993

Nephron

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The aim of this study was to evaluate the role of clomiphene citrate (CC) therapy in the hypothalamus-pituitary-gonadal axis of male uremic subjects. Thirty-four patients on hemodialysis (HD) and 8 successful kidney transplant subjects (RT) were evaluated. Nine healthy males were used as controls (C). At baseline, zinc, testosterone (TEST), prolactin (PRL), FSH, LH and estradiol plasma concentrations were measured. All subjects were treated with CC (100 mg/day) for a week. The aforementioned parameters were determined again on the seventh day of CC therapy, and 3 days after drug withdrawal. Following CC, there was a rise in FSH, LH and TEST levels in all subjects (p < 0.05); it is interesting to stress that TEST became normal in HD. In addition, we observed a decrease of PRL after CC only in HD patients (p < 0.01). In summary, CC was able to partially correct most of the hormonal disturbances of the gonadal axis in uremic patients.

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Section: Discussionmentioning

confidence: 99%

Effect of Clomiphene Citrate on Hormonal Profile in Male Hemodialysis and Kidney Transplant Patients

Martín‐Malo

Benito

Castillo

et al. 1993

Nephron

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“…Similar to Zip3, ZnT2 expression is regulated by lactogenic hormones which we have recently documented at least in part, results from transcriptional regulation through prolactin signaling mechanisms [92]. ZnT4 is expressed ubiquitously, but abundantly expressed in mammary gland, brain and kidney [3,4,41,49,69]. ZnT4 is localized to intracellular vesicles and to the trans-Golgi network of normal rat kidney cells [38].…”

Section: Mammary Gland Zinc Metabolism and Lactationmentioning

confidence: 99%

Mammary gland zinc metabolism: regulation and dysregulation

2009

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Zinc (Zn) is required for numerous metabolic processes serving both a structural and catalytic role. The mammary gland has a unique Zn requirement resulting from the need to also transfer an extraordinary amount of Zn into milk (~0.5-1 mg Zn/day) during lactation. Impairments in this process can result in severe Zn deficiency in the nursing offspring which has adverse consequences with respect to growth and development. Moreover, dysregulated mammary gland Zn metabolism has recently been implicated in breast cancer transition, progression and metastasis, thus there is a critical need to understand the molecular mechanisms which underlie these observations. Tight regulation of Zn transporting mechanisms is critical to providing an extraordinary amount of Zn for secretion into milk as well as maintaining optimal cellular function. Expression of numerous Zn transporters has been detected in mammary gland or cultured breast cells; however, understanding the molecular mechanisms which regulate mammary Zn metabolism as well as the etiology and downstream consequences resulting from their dysregulation is largely not understood. In this review, we will summarize the current understanding of the regulation of mammary gland Zn metabolism and its regulation by reproductive hormones, with a discussion of the dysregulation of this process in breast cancer.

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“…There is a high prevalence of sexual dysfunction among peo ple who dialyse. Although psychological fac tors are important in the aetiology of sexual dysfunction in ESRD [107], important or ganic contributors include low testosterone levels and hvperprolactinaemia [108], possi bly associated with zinc deficiency [109], These physiological factors are often reversed by transplantation [108]. While some re searchers have reported that sexual function improves after transplantation [48], others have failed to confirm this [110][111][112][113].…”

Section: Quality Of Lifementioning

confidence: 99%

Psychosomatic Aspects of End-Stage Renal Failure

Sensky

1993

Psychother Psychosom

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End-stage renal failure (ESRD) is more than a typical chronic disease. Its treatment includes features which arguably make this condition unique. Selected psychosomatic aspects of ESRD are reviewed, including psychiatric morbidity, patients’ adherence to their treatments, quality of life and the emotional impact on staff involved in treating patients with ESRD. Rather than presenting a comprehensive review of the results of published research, particular emphasis is laid on the critical appraisal of the methodology of published studies, to examine the extent to which these have provided answers to clinically important questions.

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Effect of Zinc Supplementation on Hyperprolactinaemia in Uraemic Men

Cited by 31 publications

References 21 publications

Effect of Clomiphene Citrate on Hormonal Profile in Male Hemodialysis and Kidney Transplant Patients

Effect of Clomiphene Citrate on Hormonal Profile in Male Hemodialysis and Kidney Transplant Patients

Mammary gland zinc metabolism: regulation and dysregulation

Psychosomatic Aspects of End-Stage Renal Failure

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